我院药品不良反应报告分析

Reporting analysis of adverse drug reaction in our hospital

目的分析该院2012年药品不良反应/事件(ADR/ADE)监测报告,促进临床合理用药,降低ADR发生率。方法该院2012年1-12月收集上报ADR报告216例,按患者基本情况、报告人职业、药物种类、临床表现、给药途径等方面进行统计分析。结果 216例ADR中,主要为一般ADR,共145例(67.1%);主要由医师上报,共143例(66.2%);患者年龄0～84岁,以0～19岁年龄段最多,共46例(21.3%);引起ADR的药品以抗微生物药为主,共74例(34.3%);引起ADR的抗感染药物以头孢菌素为主,共24种(32.4%);主要累及皮肤及其附件,共68例次(24.8%);给药方式以静脉滴注给药为主,共143例(66.2%)。结论医院应健全临床药学机构和相应制度,医药人员应开展ADR科研协作,促进临床合理用药,减少或避免ADR的发生。

Objective To analyze the adverse drug reaction/event （ADR/ADE） monitoring reports of our hospital in 2012,in order to promote clinical rational drug usage and reduce the incidence rate of ADR. Methods Retrospectively analyzed 216 cases of ADR,reported in our hospital from January 2012 to December 2012,collecting and reporting,descriptive statistical analysis carried out according to the basic situation,occupation of reporting human,drug type,clinical manifestation,the route of administration. Results Among 216 cases reports,mainly for general ADR,145 cases （67.15%） ; primarily reported by physicians,143 cases （66.2%） ; patient age 4d～84 years,0～19 years accounted for the largest percentage,46 cases （21.3%） ; ADR mainly occurrenced of antimicrobial drugs,74 cases （34.3%） ; ADR caused by anti-infective drugs cephalo-sporin-based,24 cases （32.4%） ; mainly involving the skin and its appendages,68 cases （24.8%） ; administration mode was mainly of intravenous infusion administration,143 cases （66.2%） . Conclusion Hospitals should improve clinical pharmacy institutions and the corresponding system,medical personnel should conduct ADR research collaboration,in order to promote rational drug usage and reduce or avoid the occurrence of ADR.