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习惯性流产与人类白细胞抗原DQB1基因多态性的相关性 被引量：4

Relativity between habitual abortion and human leukocyte antigen DQB1 gene polymorphism
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摘要 目的探讨习惯性流产(HA)与人类白细胞抗原DQB1(HLA-DQB1)基因多态性的关系。方法采用聚合酶链反应-限制性片段长度多态性方法分析60例HA患者和60例正常生育妇女的DQB1基因型。结果 HA组患者的DQB1*0303等位基因的频率为31.67%,明显高于正常妇女组10.00%的等位基因的频率,差异有统计学意义(χ2=8.54,P<0.01)。结论 DQB1*0303单元型可能与HA的发病密切相关。 Objective To discuss the relationship between habitual abortion（HA） and human leukocyte antigen DQB1（HLA-DQB1） gene polymorphism.Methods 60 cases of HA patients and 60 normal fertile women were analyzed by polymerase chain reaction-restriction fragment length polymorphism for DQB1 genotypes.Results Statistical significant difference（χ2=8.54,P0.01） existed in DQB1＊0303 allele frequency between the two groups,with 31.67% in HA pa tients group,significantly higher than 10.00% allele frequency of the control group.Conclusion DQB1＊0303 haplotype may be closely related to the morbidity of HA.
作者 杨旭 阿米娜 王琳
机构地区 新疆医科大学第五附属医院妇科
出处 《中国当代医药》 2013年第19期51-52,共2页 China Modern Medicine
关键词 习惯性流产 人类白细胞抗原 多态性 Habitual abortion Human leukocyte antigen Polymorphism
分类号 R711 [医药卫生—妇产科学]
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参考文献8

  • 1Salazar EL,Calzada L. The role of progesterone in endometrial estradi- ol-and progesterone-receptor synthesis in women with menstrual disor- ders and habitual abortion[J].Gynecol Endocrinol,2007,23 (4):222- 225.
  • 2Quintero-Ramos A,Valdez-Velazquez LL, Hern6ndez G, et al.Assess- ment of five thrombophilic genetic polymorphisms among couples with habitual abortion[J].Gac Med Mex ,2006,142(2):95-98.
  • 3鲁平,张爱爱,于峰,靳伟东.习惯性流产与抗心磷脂抗体检测的相关性分析[J].哈尔滨医科大学学报,2011,45(6):606-607. 被引量：13
  • 4Bronson PG,Mack SJ,Erlich HA,et al. A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric [J]. Hum Mol Genet,2013,15,22 (2) :252-261.
  • 5Hussain N ,Jaffery G. Distribution of human leukocyte antigen alleles in systemic lupus erythematosus patients with angiotensin converting enzyme insertion/deletion polymorphism [J].Bosn J Basic Med Sci, 2013,13(1 ) :57-62.
  • 6Saha I, Mazzocco G, Plewczynski D. Erratum to : Consensus classifica- tion of human leukocyte antigen class II proteins[J].Immunogenetics, 2013,65(4) :313.
  • 7AbbasA,Tripathi P, Naik S,et al. Analysis of human leukocyte antigen (HLA) G polymorphism in normal women and in women with recur- rent spontaneous abortions[J]. Eur J Immunogenet, 2004,31 (6) : 275- 278.
  • 8Sipak SO, Cybulski C, Lubinski J,et al. HLA-G polymorphism in a Pol- ish population and reproductive failure[J]. Tissue Antigens,2008,71 ( 1 ) :67-71.

二级参考文献10

  • 1常笑雪,黄鹂,杨石强,赵荣坡,张鑫.早期自然流产的免疫学因素研究与分析[J].中国妇幼保健,2005,20(16):2036-2037. 被引量：32
  • 2Di Simone N,Meroni PL,de Papa N,et al.Antiphospholipid anti-bodies affect trophoblast gonadotropin secretion and invasivenessby binding directly and through adhered beta2-glycoprotein Ⅰ[J].Arthritis Rheum,2000,43(1):140-150.
  • 3Gharavi AE,Pierangeli SS,Levy RA,et al.Mechanisms of pregnancy loss in antiphospholipid syndrome[J].Clin Obstet Gyneco,2001,44(1):11-19.
  • 4Wramsby ML,sten LS,Bremme K.Primary habitual abortions are associated with high frequency of factorV Leiden mutation[J].Fertil Steril,2000,74(5):987-991.
  • 5Sebire N J,Fox H,Backos M,et al.Defective endovascular trophoblnst in vasion in primary antiphospholipid antibody syndrome associated early pregnancy failure[J].Hum Reprod,2002,17(4):1067-1071.
  • 6Rchunan G.Evaluation of anticardiolipin antibodies and antiphospatidy lserine anti-bodies in women with recurrent abortion[J].Indian J Med Sci,2005,59(8):347-352.
  • 7Bose P,Black S,KadyrovM,et al.Adverse effects of lupus anticoagulantpositive blood sera on placentalviability can be prevented by heparinin vitro[J].Am J Obstet Gyneco,2004,191 (6):2125-2131.
  • 8沈寅琛,陆洪波.早期自然流产与抗心磷脂抗体的关系[J].中国现代医生,2008,46(5):65-65. 被引量：10
  • 9许国强,邱金东,刘英杰.2906例免疫性不孕患者血清抗体检测结果分析[J].河南大学学报（医学版）,2008,27(1):43-44. 被引量：18
  • 10辛力.免疫学因素与反复自然流产关系的研究进展[J].中国优生与遗传杂志,2003,11(4):143-144. 被引量：2

共引文献12

同被引文献74

  • 1段德义,张海燕,徐群渊,李颖,杨慧.反义HLA-A2和GDNF共表达逆转录病毒载体的构建和鉴定[J].神经解剖学杂志,2005,21(2):103-107. 被引量：4
  • 2李颖,杨慧,徐群渊,姬曼,张耀芬,段德义.反义HLA-A2 cDNA抑制人成纤维细胞于大鼠脑内移植后的免疫排斥反应[J].神经解剖学杂志,2005,21(2):113-118. 被引量：3
  • 3薛松果,杨珏琴,姚芳娟,许玲娣,范丽安.正常妊娠和原因不明习惯性流产者HLA-G基因14bp缺失多态性研究[J].现代免疫学,2006,26(4):318-321. 被引量：12
  • 4刘梅,龚伊,张先君.单核苷酸多态性在原因不明习惯性流产中的研究进展[J].生殖与避孕,2007,27(2):128-132. 被引量：4
  • 5Wang X, Jiang W, Zhang D.Association of 14-bp insertion/ deletion polymorphism of HLA-G gene with unexplained recurrent spontaneous abortion : a meta-analysis[J].Tissue Antigens, 2013, 81,108-115.
  • 6Wu Z, You Z, Zhang C, et al.Association between functional polymorphisms of Foxp3 gene and the occurrence of unexplained recurrent spontaneous abortion in a Chinese Hart population[J]. Clin Dev Immunol, 2012,896458.
  • 7Song G, Yah J, Zhang Q, et al. Association of tissue inhibitor of metalloproteinase gene polymorphisms and unexplained recurrent spontaneous abortions in Hart Chinese couples[J].Eur J Obstet Gyneol Reprod Biol, 2014,181:84-8.
  • 8Liu C, Wang J, Zhou S, et al.Association between-238 but not-308 polymorphism of Tumor necrosis factor alpha (TNF- alpha) v and unexplained recurrent spontaneous abortion (URSA) in Chinese population[J].Reprod Biol Endocrinol, 2010,28 (8) : 114.
  • 9Pan H, Suo P, Liu C, et al. The ESR1 gene in unexplained recurrent spontaneous abortions[J].Syst Biol Reprod Med, 2014, 60 (3) :161-4.
  • 10Hu J, Wang J, Xiang H, et al. Association of polymorphisms in the estrogen receptor 13 (ESR2)with unexplained recurrent spontaneous abortion (URSA) in Chinese population[J].J Matem Fetal Neonatal Med, 2012, 25 ( 9 ) : 1727-9.

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中国当代医药
2013年 第19期

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