奥美拉唑联合雷贝拉唑治疗消化性溃疡的效果观察

Effect observation of omeprazole combined with rabeprazole in the treatment of peptic ulcer

目的观察奥美拉唑与雷贝拉唑联合治疗消化性溃疡的临床疗效。方法将本院2010年1月～2011年12月收录的80例消化性溃疡患者随机分为对照组和观察组,两组患者均给予基础治疗,对照组给予口服奥美拉唑治疗,观察组在对照组的治疗基础上给予口服雷贝拉唑治疗,观察两组的治疗效果。结果观察组的临床治疗总有效率为92.5%,对照组的临床治疗总有效率为80.0%,观察组临床治疗总有效率明显高于对照组,两组差异有统计学意义(P<0.05);两组患者的不良反应发生率比较,差异无统计学无意义(P>0.05)。结论奥美拉唑与雷贝拉唑联合治疗消化性溃疡效果显著,有效提高了临床治疗效果,并且不良反应也较少,值得临床中应用与推广。

Objective To observe the clinical efficacy of omeprazole and rabeprazole with combined treatment on pep tic ulcer.Methods Eighty cases of peptic ulcer patients included by our hospital from January 2010 to December 2011 were randomly divided into control group and observation group.Two groups＇ patients were all given basic treatment.The control group was given oral omeprazole treatment,and observation group were also given oral rabeprazole treat ment,except for given oral omeprazole treatment same with control group,and then the treatment effect of two groups was observed.Results The total effectiveness of clinical treatment of the observation group was 92.5%,and total effi ciency of clinical treatment of the control group was 80.0%,rhe total clinical efficiency of the observation group was obviously higher than that of the control group,there was significant difference（P0.05）;there was no significant difference about the adverse reaction rate of the two groups（P0.05）.Conclusion In clinical treatment,the effect of using omeprazole and rabeprazole on combined treatment peptic ulcer is significant,it effectively improves the clinical treat ment effect,and the adverse reactions are relatively small,then it is worthy of application and promotion in clinical practice.