Detection of Delayed Hypersensitivity to Fonsecaea pedrosoi Metabolic Antigen （Chromomycin）in Healthy People in an Endemic Area
Detection of Delayed Hypersensitivity to Fonsecaea pedrosoi Metabolic Antigen （Chromomycin）in Healthy People in an Endemic Area
摘要
The CBM （chromoblastomycosis） is a disease caused by dematiaceous fungi, which has the species Fonsecaea pedrosoi as main agent. This fungus is found in warm and moist climates, characteristically found in the amazonic lands of the region, where its environmental isolation was once described. This research aimed to identify the healthy population exposed to agent F. pedrosoi in four villages located in the Legal Amazon. In order to clarify the risk factors for allergic immune exposure, a survey was conducted by the technique of delayed skin reaction （IDR） with the metabolic antigen （chromomycin） in 449 healthy individuals. The results showed that 14.9% （67 subjects） were IDR positive, with induration 〉 5 mm. Multivariate analysis with logistic regression for risk factors： living in the village of Z6 Pedro （municipality of Bacabeira in the state of Maranhao, Brazil）,
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