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Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis

Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis
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摘要 Prostate cancer is one of the most common malignancies.The development and progression of prostate cancer are driven by a series of genetic and epigenetic events including gene amplification that activates oncogenes and chromosomal deletion that inactivates tumor suppressor genes.Whereas gene amplification occurs in human prostate cancer,gene deletion is more common, Prostate cancer is one of the most common malignancies.The development and progression of prostate cancer are driven by a series of genetic and epigenetic events including gene amplification that activates oncogenes and chromosomal deletion that inactivates tumor suppressor genes.Whereas gene amplification occurs in human prostate cancer,gene deletion is more common,
作者 Changsheng Xing Xiaoying Fu Xiaodong Sun Jin-Tang Dong
机构地区 Department of Genetics and Cell Biology Department of Hematology and Medical Oncology Department of Pathology
出处 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2013年第6期315-318,共4页 遗传学报（英文版）
基金 supported by the grants from the National Cancer Institute,National Institutes of Health(Nos. R01CA87921 and R01CA171189) the National Natural Science Foundation of China(No.81130044)
关键词 Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis
分类号 R737.25 [医药卫生—肿瘤]
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  • 1Abate-Shen, C., Banach-Petrosky, W.A., Sun, X., Economides, K.D., Desai, N., Gregg, J.E, Borowsky, A.D., Cardiff, R.D., Shen, M.M., 2003. Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res. 63, 3886-3890.
  • 2Abdulkadir, S.A., Magee, J.A., Peters, T.J., Kaleem, Z., Naughton, C.K., Humphrey, EA., Milbrandt, J., 2002. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol. Cell. Biol. 22, 1495-1503.
  • 3Anderson, ED., McKissic, S.A., Logan, M., Roh, M., Franco, O.E., Wang, l., Doubinskaia, I., Meer, R., Hayward, S.W., Eischen, C.M., Eltoum, I.E., Abdulkadir, S.A., 2012. Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis. J. Clin. Invest. 122, 1907-1919.
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Journal of Genetics and Genomics
2013年 第6期

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