精氨酸加压素对沙土鼠缺血脑区是β内啡肽和强啡肽A_(1-13)的影响

The Effect of Arginine Vasopressin on β-endorphin and Dynorphin A_(1-13) Contents in Cerebral Ischemic Regions of Mongolian gerbils

本实验用放射免疫测定法观察了精氨酸加压素(AVP)对蒙古沙土鼠缺血脑区β内啡肽样免疫活性物质(ir-β-EP)和强啡肽A_(1-13)免疫活性物质(ir-Dyn A_(1-13))的影响。结果显示,侧脑室注射AVP后,缺血皮层和下丘脑ir-β-EP含量明显升高,ir-Dyn A_(1-13)含量则明显降低。侧脑室注射AVP抗血清后,缺血皮层和下丘脑ir-β-EP含量显著降低,而ir-Dyn A_(1-13)含量尢明显变化。

The effects of arginine vasopressin (AVP) on the contents of ir-β-EP and ir-Dyn A1-13 in ischemic brain regions of Mongolian gerbils were observed with radioimmunoassay in this study.The results showed that the contents of ir-β-EP were significantly increased and those of ir-Dyn A1-13 were decreased in ischemic cortex and hypothalamus after injection of AVP into the lateral ventricle. However, the contents of ir-β- EP were markedly decreased and those of ir-Dyn A1-13 were unchanged significantly in the ischemic cortex and hypothalamus after intraventricular infusion of AVP antiserum.