早期肺泡灌洗治疗有机磷农药中毒并重症吸入性肺炎临床分析

The clinical exploration of early alveolar lavage in patients with organophosphorous pesticide poisoning complicated with servere inhaled pneumonia

目的:探讨肺泡灌洗治疗有机磷农药中毒并发重症吸入性肺炎的临床疗效。方法:回顾性分析有机磷农药中毒并重症吸入性肺炎38例患者中综合治疗组(对照组)15例与在综合治疗基础上给予早期多次肺泡灌洗治疗(治疗组)23例患者的呼吸频率、体温、白细胞、动脉血氧分压(PaO2)及预后指标。结果:治疗组白细胞、PaO2较对照组改善明显,差异有统计学意义(P<0.05),而呼吸频率、体温差异无统计学意义(P>0.05)。治疗组胸片阴影消失时间、呼吸机使用时间和lCU内住院时间、病死率均显著少于对照组(P<0.05)。结论:早期肺泡灌洗治疗有机磷农药中毒并重症吸入性肺炎能显著改善患者的临床症状和预后,是一项有效的治疗措施,但呼吸频率、体温不能作为评价疗效指标。

Objective：To investigate the clinical effect of alveolar lavage in organophosphorous pesticide poison- ing complicated with servere inhaled pneumonia. Method：A total of 38 organophosphorous pesticide poisoning pa tients complicated with severe inhaled pneumonia were selected for this study. 15 patients accepting comprehensive treatment were in the control group. 23 patients accepting comprehensive treatment and early alveolar lavage treat- ment were in the treatment group. Respiration rate, temperature, leukocytes,PaO2 and prognosis were analyzed. Result：Compared wilh the control group, treatment group showed significant decrease of leukocytes and increase of Pa（）2（p^0.05）. The differences of respiration rate and temprature were not significant（p^0.05）. The X--ray shadow vanishing period,ventilation period,hospitalization period and death rate were remarkably decreased in the treatment group（P〈0.05）. Conclusion：Early alveolar lavage is an effective treatment to improve the clinical symp- toms and prognosis of patients with organophosphorous pesticide poisoning complicated with severe inhaled pneu- monia. But the respiration rate and temperature cannot be applied as prognosis marker.