拉贝洛尔治疗妊娠高血压危象疗效观察

Treatment of hypertensive emergencies in pregnancy with Labetalol

目的:观察静脉使用拉贝洛尔治疗妊娠高血压危象的疗效。方法:妊娠高血压危象55例患者分为两组,A组(30例)使用拉贝洛尔注射液,以(0.5～1)mg/min速度静脉微泵输入,2h左右血压达安全范围,再予(70～208)ug/min静脉维持;B组(25例)采用硝苯地平10mg口服,q8h,两组同时使用硫酸镁预防子痫发生。在此期间监控血压,心电变化。结果:A组用药2h后显效23例,有效6例,显效率76.7%,总有效率96.7%。36h平均血压为(106±13)mmHg(1mmHg=0.133kPa)。B组用药2h后显效8例,有效10例,显效率32%,总有效率72%。36h平均血压为(118.9±10.2)mmHg,出现心动过速8例。结论:拉贝洛尔治疗妊娠高血压急症疗效确切,降压平稳,未见有严重不良反应。

Objective： To observe therapeutic of Labetalol for pregnancy induced hypertensive crisis. Method： 55 cases of pregnancy induced hypertension crisis were divided into two groups. G-roup A （30 cases） of hypertensive emergencies in pregnancy were treatment the use of Labetalol by the micro pump intravenous infusion with the speed of （0.5-1） rag/rain,then 70-200 ug/min intravenous maintenance continuously after the blood pressure has been reduced to the safe range after around 2 hours. Group B （25 cases） with Nifedipine tablets 10 mg oral, Q8H. At the same time two groups the use of Magnesium sulfate to prevent eclampsia seizures. During this time, we should keep monitoring the blood pressure and ECG changes. Result：In A group after 2 hours＇ treatment,there were markedly effects on 23 patents and effects on 6 patients. The markedly effective rate was 76.7 % ,the total ef- ficiency was 96.7 %. 36 hours＇ average blood pressure was （106 ＋ 13） mmHg. t3 group after 2 hours＇ treatment, there were markedly effects on 8 patents and effects on 10 patients. The markedly effective rate was 32%,the total efficiency was 72%. 36 hours＇ average blood pressure was （118.9＋10.2） mmH. 8 cases have appeared sinus tach- ycardia. Conclusion：The therapy of use of Labetalol in the treatment of hypertension emergencies in pregnancy is effective, long standing stable, no severe side effects were observed.