期刊文献+

国际纳米药物领域专利态势分析 被引量:3

International Patent Analysis on Nanodrug
原文传递
导出
摘要 该文基于德温特专利数据库,利用TDA、Thomson Innovation等分析工具或平台对1980-2011年纳米药物领域专利进行了分析,系统揭示了30多年以来纳米药物的研发现状、技术热点以及技术分布与格局。研究发现纳米药物领域相关专利的申请数量呈现出逐年增长的态势,特别是2000年后专利申请数量呈现出明显加快的趋势;纳米药物领域专利主要集中在:超音速喷雾干燥技术、药物靶向递送、共聚物药物、多肽、抗原、树枝状大分子等方向。 In order to show the development status of nanodrug technology, the analysis of patent literature during 1980-2011 (data from Derwent Innovations Index of ISI WoK) is carried out by using analysis tools TDA and Thomson Innovation. The status of research and development of nanodrug in the 30 years, hot spots, as well as the technical distribution pattern were revealed. The study found that the number of related patents in the field of nanodrug application showing a growth trend year by year, especially after 2000, showing a significantly accelerated trend; patents in the field are mainly concentrated in Supersonicjet Spray Drying, Drug Targeting Delivery, Copolymer Drug, Peptide, Antigen, Dendrimers, etc.
出处 《科学观察》 CSSCI 2013年第3期58-63,共6页 Science Focus
关键词 纳米药物 专利分析 专利地图 nanodrug, patent analysis, patent map
  • 相关文献

参考文献5

  • 1王子妤,张东生.纳米药物的研究进展[J].东南大学学报(医学版),2004,23(2):131-135. 被引量:31
  • 2Cancer nanotechnology plan. http://nano.cancer.gov/objects/ pdfs/Cancer_Nanotechnology_Plan-508.pdf.
  • 3Nanomedicine Roadmap Initiative. 2005. http://nihroadmap,nih.gov/nanomedicine/index.asp.
  • 4文声.纳米药物——21世纪医学技术的重要方向[J].技术与市场,2009,16(4):93-94. 被引量:8
  • 5Petros R A, DeSimone J M. Strategies in the design of nanoparticles for therapeutic applications. Nature Reviews Drug Discovery, 2010, 9: 615-627.

二级参考文献23

  • 1MUHLEN A Z, MEHNERT W. Drug release and release mechanism of prednisolone loaded solid lipid nanoparticles[J].Pharmazie, 1998,53 (8): 552-559.
  • 2LI Y P, PEI Y Y, ZHANG X Y, et al. PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats [ J ]. J Control Rel, 2001,71 (2): 203-211.
  • 3BOGUNIA-KUBIK K, SUGISAKA M. From molecular biology to nanotechnology and nanomedicine[ J ]. Biosystems, 2002,65(2-3): 123-138.
  • 4GELPERINA S E,KHALANSKY A S, SKIDAN I N,et al.Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma[J ]. Toxicol Lett, 2002,126(2): 131-141.
  • 5LANZA G M,YU X,WINTER P M,et al. Targeted antipro liferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agents: implications for rational therapy of restenosis[J ]. Circulation, 2002,106(22) :2842
  • 6MARIA M G, BLANCO K, CRUZE M E M,et al. Formulation of L-asp aragrnase-loaded PLGA nanoparticles: in fluence of polymerproperties on enzyme loading activity and in vitro release[ J ]. Controlled Release, 1998,52( 1/2): 53-62.
  • 7MITRA S, GAUR U, GHOSH P C, et al. Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanopartieals as carrier[J ]. J Control Release,2001,74(1-3) :317-323.
  • 8DAVIS S S. Biomedical applications of nanotechnology-implications for drug targeting and gene therapy [ J ]. Trends Biotechnol, 1997,15(6) :217-224.
  • 9NA K, BUM LEE T, PARK K H, et al. Self-assembled nanoparticles of hydrophobically-modified polysaccharide bearing vitamin H as a targeted anti-cancer drug delivery system[J]. Eur J Pharm Sci,2003,18(2): 165-173.
  • 10KONG G, BRAUN R D, DEWHIRST M W. Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size[ J ]. Cancer Res, 2000,60 (16): 4440-4445.

共引文献37

同被引文献40

  • 1郝英魁,杨学东.载药壳聚糖纳米粒的研究进展[J].中国药学杂志,2005,40(17):1292-1295. 被引量:30
  • 2林爱华,平其能.壳聚糖载药纳米粒研究进展[J].中国药业,2006,15(21):25-27. 被引量:12
  • 3林爱华,刘奕明,平其能.壳聚糖纳米粒表面游离氨基与纳米粒特性研究[J].药学学报,2007,42(3):323-328. 被引量:24
  • 4Petros RA, DeSimone JM. Strategies in the design of nanoparticles for therapeutic applications [ J ]. Nat Rev Drug Discov, 2010, 9(8) ;615-627.
  • 5Takhar P, Mahant S. In vitro methods for nano- toxicity assessment., advantages and applications [J]. Arch Appl Sci Res, 2011, 3(2) :389-403.
  • 6Greish K, Thiagarajan G, Ghandehari H. In vivo methods of nanotoxicology[ J]. Methods Mol Biol, 2012, 928,235-253.
  • 7Nel A, Xia T, M&dler L, Li N. Toxic potential of materials at the nanolevel [ J ]. Science, 2006, 311 (5761) :622-627.
  • 8Editorial. The dose makes the poison[ J]. Nat Nanotechnol, 2011,6(6):329.
  • 9Dhawan A, Sharma V, Devendra P. Nanomateri- als : A challenge for toxicologists [ J ]. Nanotoxicol, 2009, 3 (1) :1-9.
  • 10Lin W, Huang YW, Zhou XD, Ma Y. In vitro toxic- ity of silica nanoparticles in human lung cancer cells [ J ]. Toxicol Appl Pharmacol, 2006, 217 ( 3 ) : 252-259.

引证文献3

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部