灵芝胶囊治疗鹅膏毒蕈中毒69例临床观察

69 cases of Amanita mushroom poisoning treated by Ganoderma Capsule

目的探讨灵芝胶囊治疗鹅膏毒蕈中毒的临床疗效及对脏器功能的保护作用。方法将69例鹅膏毒蕈中毒病例按入院时病情轻重分为轻症组15例、中症组22例及重症组32例,给予灵芝胶囊口服治疗,观察其临床疗效。并将重症组32例设为治疗组与本科历史资料(2002-2005年)重症组(灵芝煎剂治疗)设为对照组进行比较,评价其疗效。观察指标:(1)临床疗效;(2)实验室指标:总胆红素(STB)、胆汁酸(BA)、谷丙转氨酶(ALT)、谷草转氨酶(AST)。结果 3组患者经口服灵芝胶囊治疗,临床症状迅速缓解,实验指标STB、BA、ALT、AST 4项仅出现一过性升高,然后迅速恢复正常。治疗组与对照组的临床疗效相近,差异无统计学意义(P>0.05)。结论灵芝胶囊在治疗鹅膏毒蕈中毒方面,与灵芝煎剂有等同疗效,可替代灵芝煎剂。

Objective To observe the therapeutic effects of Ganoderma Capsule on amanita mushroom poisoning and protecting organs.Methods From 2009 to 2011,69 cases of acute Amanita mushroom poisoning were divided into 3 groups according to the degree of poisoning： 15 patients in mild symptom group,22 patients in moderate symptom group and 32 patients in severe symptoms group.3 groups were all given Ganoderma Capsule and clinical effects were observed.Severe symptom group was set up as the treatment group and compared to the control group which was 34 patients with severe symptoms treated by ganoderma decoction in records between 2002 to 2005.The clinical curative effects,the levels of serum total bilirubin（STB）,bile acid（BA）,glutamic-oxaloacetic transaminase（ALT） and glutamic-pyruvic transaminase（AST） were observed.Results The patients＇ clinical symptoms were quickly relieved in 3 recent groups;the levels of STB,BA,ALT and AST had transient increase but returned normal immediatly.The therapeutic effects in treatment group had no significant superiority to those in control group（P0.05）.Conclusion Ganoderma Capsule is as effective as ganoderma decoction in treating acute Amartita mushroom poisoning.It can replace ganoderma decoction in clinical.