急性淋巴细胞白血病19例的免疫分型

Immunologic Classification of Acute Lymphocytic Leukemia: A Report of 19 Cases

应用11～13种单克隆抗体检测急性淋巴细胞白血病(ALL)的细胞表面分化抗原。按其特异性抗原标记,19例ALL中属T-ALL4例、B-ALL4例、C-ALL7例、AUL2例、H-ALL2例。其中B-ALL、T-ALL和H-ALL比例较高,其原因与使用单克隆抗体种类较多,特别是与特异性较强的CD_(19)和CD_7有关。又按Foon 1986年分型方案分类,此5型可归纳为T-ALL、非T-ALL和H-ALL3类。这种分型方法有助于判断恶性细胞的来源和分化阶段,加深对ALL细胞本质的了解。

Immunologic classification of acute lymphocytic leukemia (ALL) was carried out by using 11 - 13 kinds of monoclonal antibodies against human leucocyte differentiation antigens in 19 cases. The results showed that of these 19 cases, there were T-ALL in 4, B-ALL in 4, C-ALL in 7, AUL in 2 and hybrid type of ALL (H-ALL) in 2. The 5 types mentioned above could also be classified, according to the immunologic criteria described by Foon in 1986, into 3 major groups: T-ALL, non-T-ALL and H-ALL. The Foon's classification method is useful for judgement of malignant cell source and differentiated stage, and for further understanding the nature of ALL cells.