Ⅱ期结肠腺癌组织P-STAT5蛋白表达及其临床意义

Study on expression and clinical value of P - STATS in stage Ⅱ colonic adenocarcinoma

目的探讨P—STAT5蛋白在Ⅱ期结肠腺癌组织中的表达情况及其与Ⅱ期结肠腺癌患者的临床病理特征和预后生存的关系。方法采用免疫组织化学SP法检测122例Ⅱ期结肠腺癌组织标本中P—STAT5蛋白的表达情况。结果P—STAT5蛋白表达定位于细胞质；P—STAT5蛋白表达与肿瘤分化程度相关（P=0．033）；P—STAT5蛋白阳性表达与更短预后生存相关（P=0．047，Log-rank test），但不是Ⅱ期结肠腺癌独立的预后判定指标（P=0．053，HR：2．41）。结论P-STAT5蛋白的表达与Ⅱ期结肠腺癌患者预后相关，检测P—STAT5的表达可能对Ⅱ期结肠腺癌患者术后辅助治疗的选择有参考价值。

Objective STATS activation（ Phospho - STATS, P - STATS ） has been observed in a variety of human tumors. Many studies have found that poor prognosis is associated with the expression of phospho - STATS. However,it is not clear how activated STATS is expressed in colon cancer. In this study,we aimed to investigate phospho -STATS expression and its relationship with clinicopathological factors and overall survival in Stage Ⅱ colonic adenocarcinoma. Methods 122 histological samples of Stage Ⅱ colonic adenocarcinoma were selected for this study. Immunohistochemistry was used to detect the expression of phospho - STATS. Results Phospho - STATS expression was observed in the cytoplasm of colonic adenocarcinoma cells. A significant relationship was found between phospho - STATS expression and tumour differentiation（ P = 0.033）. Univariate analysis showed that shorter overall survival was correlated with phospho - STATS immunoreactivity（P = 0.047, log - rank test）. Multivariate analysis showed that phospho - STATS was not an independent predictor in relation with shorter overall survival （ P = 0. 053, hazard ratio = 2.41 ）. Conclusion Expression of phospho - STAT5 is correlated with shorter survival in patients with Stage Ⅱ colonic adenocareinoma. It may be of great value in evaluating the expression of phospho - STATS for adjuvant systemic therapy in surgically treated patients with Stage Ⅱ colonic adenocarcinoma.