17种化合物的抗突变效应

Antimutagenic Effects of 17 Compounds

应用SOS显色试验研究了(1)半胱氨酸、(2)桂皮酸、(3)芦丁、(4)鞣酸、(5)二氧化锗、(6)5氟尿嘧啶、(7)叶绿素铜钠、(8)β谷固醇、(9)维生素C、(10)香豆素、(11)维生素E、(12)L谷胱甘肽(氧化型)、(13)L谷胱甘肽(还原型)、(14)亚硒酸钠、(15)有机锗、(16)蛋氨酸和(17)脯氨酸17种化合物对由亚硝基胍(MNNG)、甲基磺酸甲酯(MMS)、苯(并)芘 [B(a)P]和紫外线(UV)诱导的SOS应答反应的抑制和抗突变作用。结果表明化合物1～15具有抑制效应,化合物2～8,10～11具有抗突变效应,桂皮酸是唯一兼有2种效应,并对4种致突物均有效的化合物。本文讨论了抗突物的作用模式,特异性和作用点。

The inhibitory and antimutagenic effects of 17 compounds, cysteine (1), cinnamic acid (2), rutin (3), tannic acid (4), germanium dioxide (5), fluro uracil (6), sodium copper chlorophylline (7), B-sitosterol (8), vitamin C (9), coumarin (10), vitamin E (11), L-glutathione (oxidized form) (12), L-glutathione (reduced form) (13), sodium selenile (14), organic germanium (15), L-methioine (16) and proline (17) on the SOS response induced by N-methyl-N'-nitro-N-nitrosoguanidine, niethly muthanesulfonate, benzo (a)pyrine and UV were studied by using SOS chromotest. The results showed that compounds 1~15 revealed inhibitory effects, and compounds 2~8 and 10-11 revealed antimutagenic effects. It was demonstrated that cinnamic acid is the best antimutagen among 17 compounds. Cinnamic acid has not only inhibitory effect but also antimutagenic activity towards a wide variety of mutagens/carcinogens. The modes, specificity and end point of action of antimutagens are discussed.