摘要
近年来以G-四链体DNA为药物靶点的研究引起了人们的广泛关注,G-四链体与其配体相互作用的研究方法也多种多样。本文对研究G-四链体形成的结构,配体与G-四链体结合能力,配体与G-四链体结合模式等三个方面的技术方法进行了综述。
In recent years,research of small molecular ligands,especially antitumor prodrugs,targeting G-Quadruplex DNA has received widespread concern and attention.Several analytical techniques are used to study such interactions.This paper reviewed the experimental methods of studying the structure of G Quadruplex,the binding ability and the interaction model between G-Quadruplex and its ligands.
出处
《浙江化工》
CAS
2013年第6期18-22,共5页
Zhejiang Chemical Industry
关键词
G-四链体
配体
研究方法
G-quadruplex
ligands
analytical techniques