研究G-四链体与其配体相互作用的技术方法概述

A Review of Experimental Methods for Studying the Interactions between G-Quadruplex and Its Ligands

近年来以G-四链体DNA为药物靶点的研究引起了人们的广泛关注,G-四链体与其配体相互作用的研究方法也多种多样。本文对研究G-四链体形成的结构,配体与G-四链体结合能力,配体与G-四链体结合模式等三个方面的技术方法进行了综述。

In recent years,research of small molecular ligands,especially antitumor prodrugs,targeting G-Quadruplex DNA has received widespread concern and attention.Several analytical techniques are used to study such interactions.This paper reviewed the experimental methods of studying the structure of G Quadruplex,the binding ability and the interaction model between G-Quadruplex and its ligands.