齐拉西酮与氯氮平治疗精神分裂症的疗效及对代谢与生活质量的影响

Effect of ziprasidone and clozapine on the metabolism and quality of life in patients with schizophrenia

目的探讨齐拉西酮与氯氮平治疗精神分裂症的临床疗效及对代谢、生活质量的影响。方法将128例精神分裂症患者随机分为齐拉西酮组及氯氮平组,每组64例,疗程12周。采用阳性症状与阴性症状量表(PANSS)及生活质量综合评定问卷(GQOLI)评估临床疗效及生活质量。结果治疗后2组PANSS评分均显著下降(P>0.05),但2组比较差异无统计学意义(P>0.05);齐拉西酮组治疗后低密度脂蛋白(LDL-C)、体质量、BMI、胰岛素、总胆固醇(TC)水平显著低于氯氮平组(P<0.05);齐拉西酮组治疗后GQOLI总分及心理健康、躯体健康和社会功能维度评分均显著优于氯氮平组(P<0.05)。结论齐拉西酮与氯氮平临床疗效相当,但齐拉西酮对代谢无显著影响,提高患者生活质量。

Objective To explore the effect of ziprasidone and clozapine on the metabolism and quality of life in patients with schizophrenia.Methods Totally 128 cases with schizophrenia were randomly divided into ziprasidone group and clozapine group with 64 cases in each group.The course of treatment was 12 weeks.PANSS scale and GQOLI questionnaire were used to evaluate the clinical effect and life quality.Results PANSS scores greatly decreased（P0.05）,with no significant difference between two groups（P0.05）.LDL-C,body mass,BMI,insuline and TC after treatment in ziprasidone group were much lower than those in clozapine group（P0.05）.After treatment,GQOLI total scores,mental health,physical health and social function dimensions in ziprasidone group were superior to clozapine group（P0.05）.Conclusion The clinical effect in ziprasidone group and clozapine group is equivalent.Ziprasidone has no obvious effect on metabolism and can improve the patients’life quality.