亚低温对心肺复苏术后缺血缺氧性脑病的影响

Effect of mild hypothermia on ischemia anoxic encephalopathy after cardiopulmonary resuscitation

目的探讨亚低温治疗对院内心脏停搏心肺复苏(CPR)后缺血缺氧性脑病者神经功能和预后的影响。方法收集惠州市第一人民医院ICU的心肺复苏术后50例患者的临床资料,在心肺复苏成功自主循环恢复后,30例(亚低温组)接受亚低温治疗(中心体温降至32～34℃,并维持24h),20例(对照组)常规治疗,7d后比较2组患者复苏后神经功能良好率和病死率。结果在心肺复苏后第7天,亚低温组患者神经系统转归率23%(7/30)明显高于常规组15%(3/20,P<0.05);亚低温组病死率50%(15/30),常规组为55%(11/20,P>0.05)。结论亚低温对心肺复苏术后缺血缺氧性脑病患者的病死率无明显影响,但可提高神经系统转归率。

Objective To assess the effects of mild hypothermia on neurologic function and prognosis of cardiac arrest patients after cardiopulmonary resuscitation.Methods Clinical data of 50 patitents after cardiopulmonary resuscitation in ICU of Huizhou First People’s Hospital were collected.After the recovery of spontaneous circulation,30 patients were treated by mild hypothermia（letting central body temperature fall to 32～34℃,and maintaining for 24 hours）,20 patients were given routine treatment.After 7 days,the neurologic outcome and mortality of the two groups were compared.Results Seven days after CPR,good neurological function was found in 23% of patients in mild hypothermia group and 15% of the controls;the mortality was 50% in the hypothermia group,which was 55% in control group（P0.05）.Conclusion This study demonstrated that mild hypothermia could improve the neurologic outcomes,but had no obvious effect on the mortality of ischemia anoxic encephalopathy after cardiopulmonary resuscitation.