中国汉族人群IL-1B基因多态性与胃癌关系的Meta分析

The Meta analysis on the relationship between interleukin-1 gene polymorphism and gastric cancer in the Han nationality in China

目的用Meta分析的方法系统评价中国人群IL-1B基因多态性与胃癌的关系。方法检索中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP),中国硕士、博士学位论文数据库、并利用著名搜索引擎等多种方式获取相关文献。按照Cochrane系统评价的方法评价纳入研究的质量,并使用RevMan5.2软件进行统计分析。结果本研究最终纳入13个病例对照研究。对IL-1B-31而言,(C/C)基因型Meta分析显示有统计学意义,合并效应量OR合并=0.80,95%CI为(0.66～0.98),其他基因型均无统计学意义;IL-1B-511的三种基因型差异均无统计学意义。结论无论对IL-1B-31还是IL-1B-511基因多态性而言,没有证据表明在中国汉族人群中的分布与胃癌的发病有关。由于本系统评价纳入的文献数量、样本量较少,因此尚需更多的大样本、高质量的随机对照试验来验证本研究的结论。

Objective To evaluate the relationship between interleukin-1 gene polymorphism and gastric cancer in China. Methods We Searched CBM, CNKI, VIP and others databases, identified the case-control studies that referred to interleukin-1 gene polymorphism and gastric cancer for the Han nationality, assessed critically the quality of inclusive researches and applied Revman 5.2 for statistical analyses. Results 13 studies were included. The re- suits of meta-analysis showed that the total odd ratio（OR） of IL-1B-31 （C/C） was 0.80 （95~ CI O. 66~0.98）, and other genotypes had no statistical significance. Meta-analysis showed gene polymorphism of IL-1B-511 were not sta- tistical significant. Conclusion Gene polymorphism of IL-1B-511 and IL-1B-31 had no relationship with gastric cancer in the Han nationality of China. But the results of this Meta-analysis may be influenced by the lack of samples included. We expected more high quality randomized controlled trials to prove our findings.