MiR-497的研究进展

Advances of researches on MiR-497

本文概述了miR-497的生物学功能以及它在多种肿瘤、缺血性疾病等中的作用。miR-497在细胞分裂、代谢、应激以及大脑不同区域具有非常重要的生物学功能。多项研究证明miR-497在乳腺癌、结肠直肠癌、原发性腹膜癌、肾上腺素皮质癌(ACC)、黑色素瘤、脑颈部鳞状细胞癌等多种肿瘤中低表达,体内外过表达miR-497可以引起肿瘤细胞凋亡,证明miR-497在抗肿瘤方面发挥着重要作用;另外,miR-497在缺血性脑卒中也具有重要作用。因而,miR-497具有良好的临床分子靶向治疗应用前景。

This article summarizes the biological functions of miR-497 and its role in a variety of tumors and ischemic diseases. MiR-497 plays important biological roles in cell division, metabolism, stress and different brain regions. A number of studies have proved that miR-497 displays low expression in breast cancer, colorectal cancer, primary peritoneal carcinoma, epinephrine cortical carcinoma （ACC）, melanoma, brain cervical squamous cell carcinoma, and so on. Overexpression of miR-497 can cause tumor cell apoptosis in vitro, which verifies miR-497 roles in antitumor and ischemic stroke. Therefore, miR-497 has a great potential for clinical targeted molecular therapy.