摘要
根据生物活性分子叠加原理,设计、合成了5个新的5-硝基呋喃亚胺化合物,并采用IR、NMR和GS-MS等手段对化合物结构进行了表征;抗血吸虫活性实验表明:标号为3a的化合物具有一定的抗血吸虫活性,编号为3e的化合物具有良好的抗血吸虫活性,其效果接近于吡喹酮,为研究新型抗血吸虫药物提供参考.
Five new 5-nitrofuran amides derivatives were designed and synthesized according to the superposition principle of biological activities,The structures of final products were characterized by IR,NMR and GS-MS.Antischistosomal experiments indicated that the compounds 3a and 3e displayed activity against adults stages of S.japonicum in infected mice,especiallly 3e demonstrated substantial worm-killing activity which was closing to Praziquantel.This reaseach provided a reference for the new type of antischistosome medicine.
出处
《赣南师范学院学报》
2013年第3期22-25,共4页
Journal of Gannan Teachers' College(Social Science(2))
基金
国家科技支撑计划重大项目(2009BAI78B01)
国家自然科学基金(21162001和21202023)
江西省自然科学基金(20114BAB213006)
赣南师范学院科研课题(11kwz20)
