高气压预处理对山羊实验性减压病的预防作用

Preventive Effects of Hyperbaric Pretreatments on Experimental Decompression Disease in Goats

成年雄性山羊21只,分成实验组(11只)和对照组(10只)。高气压预处理的压力-时程为700 kPa-3 min;其加压和减压速度均为100 kPa/min;高气压预处理与快速减压模拟潜水之间的间隔时间为15 min。模拟潜水方案的压力-时程为600kPa-60min,其加压速度力100 kPa/min,减压速度为60kPa/min。结果显示高气压预处理可使山羊因模拟潜水快速减压而引起的体内气泡形成减少、血浆中5-HT浓度升高减少,减压病的发病率、病死率、循环血小板计数以及心前区血流气泡音的变化趋向也一致。提示高气压预处理可在一定程度上预防山羊实验性减压病。

21 male adult goats were divided into the experimental group (11 goats) and control group (10 goats). The pressure-time of hyperbaric pretreatment was 700kPa-3min. The rates of the compressions and decompressions of hyperbaric pretreatments were l00kPa/min. The intervals between hyperbaric pretreatments and simulated divings which were repidly decompressed were 15min. The pressure-time of simulated diving was 600 kPa-60min. The rates of the compressions of the simulated divings were l00kPa/min and those of the decompressions were 60kPa/min. The results indicated that hyperbaric pretreatments might reduce the bubble formation and increased 5-HT concentrations which were caused by rapid decompression after simulated divings, and that other indexes such as morbility and mortality of decompression disease, platelet count of circulation, and bubble sound of blood flow on the precardium of the goats changed coincidently. These suggest that hyperbaric pretreatments could prevent goat's experimental decompression disease in some degree.