自由基在大鼠烫伤复合内毒素血症所致的急性肺损伤中的作用

Role of Oxygen Radicals in Acute Lung Injury Induced by Burns Complicated by Cndotoxemia in Rats

本安验复制大鼠烫伤复合内毒素血症所致急性肺损伤的动物模型,观察到外周动、静脉血白细胞计数进行性降低;肺毛细血管内粒细胞数增多,内皮细胞严重受损;肺系数、肺含水量及MDA含量升高,SOD活性下降。预先给予SOD,上述指标均有改善,提示自由基在大鼠烫伤复合内毒素血症所致急性肺损伤中起重要作用。

An animal model of acute lung injury was reproduced by intravenous injection of E. coli endotoxin to burned rats. The histological changes of lung were studied using transmission electron microscope. It was found that leukocytes accumulated in the pulmonary capillaries and adhered to endothelia. The WBC count decreased gradually. The level of MDA, lung coefficient and lung water content were increased. The SOD activity was decreased. Pretreatment with SOD could improve the changes mentioned above. This study suggests that oxygen radicals play an important role in acute lung injury induced by burns complicated by endotoxemia.