通脉醒脑滴丸抗血栓与改善微循环的作用研究

Improvement Effects of Tongmai Xingnao Dripping Pills on Microcirculation and Thrombus

目的:研究通脉醒脑滴丸抗血栓和改善微循环的作用。方法:玻璃毛细管法测定小鼠凝血时间;角叉菜胶复制小鼠尾血栓模型,观察小鼠尾血栓形成情况;尾静脉注射高分子右旋糖酐复制小鼠软脑膜微循环障碍模型,观察小鼠毛细血管收缩率和血液流态变化情况。结果:295.40、147.70、73.85mg/kg剂量下,通脉醒脑滴丸具有抗凝血作用,可对抗由高分子右旋糖酐引起的小鼠软脑膜微循环障碍(P<0.05);复制模型24、48、72h后在295.40mg/kg剂量下,通脉醒脑滴丸能显著抑制体内血栓的形成(P<0.05)。结论:通脉脑醒滴丸具有抗血栓与改善微循环作用。

OBJECTIVE： To study the improvement effects of Tongmai xingnao dripping pills on microcirculation and thrombus. METHODS： The clotting time of mice was determined by glass capillary method; the thrombus model was induced by carrageenan via tail veins, and the thrombosis of tail veins were observed; microcirculation barriers of pia mater model of mice was established by high molecular dextran via tail veins, and the shrinkage of capillary and change of blood flow were observed. RESULTS： Tongmai xingnao dripping pills （295.40, 147.70, 73.85 mg/kg） had anticoagulation effect and antagonized microcirculation barriers of pia mater induced by high molecular dextran（P〈0.05）. Tongmai xingnao dripping pills （295.40 mg/kg） inhibited significantly formation of thrombosis in vivo 24、48、72 h after establishing the model（P〈0.05）.CONCLUSIONS： Tongmai xingnao dripping pills have the effect of anti-thrombosis and microcirculation improvement.