传统心血管危险因素结合炎性标志物及颈动脉斑块对冠心病预测的价值

PREDICTED VALUE OF TRADITIONAL CARDIOVASCULAR RISK FACTORS COMBINED WITH INFLAMMATORY MARKERS AND CAROTID PLAQUE FOR CORONARY DISEASE

目的探讨颈动脉内中膜厚度(IMT)、斑块指数及血清高敏C-反应蛋白(hs-CRP)浓度等指标与冠脉病变程度的关系,从而对冠心病的早期预防提供新的途径。方法对1 506例患者进行冠脉造影,颈动脉彩超及血清hs-CRP检查。根据造影结果分为对照组(814例),单支病变组(341例),双支病变组(131例)和三支病变组(220例),检测IMT、hs-CRP及计算斑块指数。结果对照组IMT、斑块指数及hs-CRP与冠心病组差异均有统计学意义。单支病变组IMT及斑块指数与双支病变组及三支病变组差异有统计学意义,而双支病变组及三支病变组组间差异无统计学意义。hs-CRP在冠心病组间差异无统计学意义。结论通过彩超检测颈动脉IMT和斑块指数及测定血清hs-CRP浓度对冠心病的早期诊断,治疗及观察其疗效有重要的临床价值。

Objective To investigate the relationship among the degree of coronary artery disease and the intima-media thickness（IMT）and plaque index of carotid and serum levels of high sensitivity C-reactive protein（hs-CRP）,and provide a new way to early prevention of coronary heart disease.Methods Totally 1506 cases received coronary angiography,carotid ultrasound and detection of serum C-reactive protein.According to the results of coronary angiography,the patients were divided into control group（814）,single-vessel disease group（314）,two-vessel disease group（131）,three-vessel disease group（220）.The IMT,plaque index and hs-CRP were detected for all subjects.Results The control group＇s IMT,plaque index and hs-CRP had significant difference to coronary heart disease（CHD）group.The single-vessel disease group＇s IMT and plaque index had significant difference to the other two group of CHD,but the two-vessel disease group and three lesions had no significant differences.The levels of Hs-CRP in different group with coronary heart disease had no significant differences.Conclusion IMT,plaque index and hs-CRP have important clinical value for the early diagnosis,treatment and evaluation the effect of coronary heart disease.