小儿肺炎支原体感染与支气管哮喘的相关性研究

Research on relationship between Mycoplasma pneumoniae infections and bronchial asthma in children

目的探讨小儿肺炎支原体感染与支气管哮喘的相关性,为临床相关研究提供参考。方法选择78例肺炎支原体抗体阳性的支气管哮喘患儿(观察组)及50例正常体检儿童(对照组),采用酶联免疫吸附试验(ELISA)检测血清sIL-2R及IL-4表达,比较两组sIL-2R及IL-4表达水平。结果观察组血清可溶性白介素-2受体(sIL-2R)及白介素-4(IL-4)水平分别为(483.5±42.6)ng/L和(32.5±2.9)ng/L,均显著高于对照组的(207.7±19.3)ng/L和(8.6±0.4)ng/L,两组比较差异有统计学意义(P<0.01)。结论小儿肺炎支原体感染与支气管哮喘密切相关,肺炎支原体感染可能是支气管哮喘的发病因素之一。

OBJECTIVE To explore the relationship between Mycoplasma pneumoniae infections and bronchial asthma in the children so as to provide the reference information for clinical research.METHODS Totally 78 children with bronchial asthma with Mycoplasma pneumoniae antibodies tested positive（the observation group） and 50normal healthy children（the control group）were chosen as the research objects.The enzyme-linked immunosorbent assay（ELISA）was taken for the detection of the serum sIL-2Rand IL-4expression.The expression levels of sIL-2Rand IL-4were compared between the two groups.RESULTS The level of serum sIL-2R of the observation group was（483.5±42.6）ng/L,significantly higher than（207.7±19.3）ng/L of the control group;the level of serum IL-4of the observation group was（32.5±2.9）ng/L,significantly higher than（8.6 ±0.4）ng/L of the control group,the difference between the two group was statistically significant（P〈0.01）.CONCLUSION Mycoplasma pneumoniae infection is closely related to the bronchial asthma,and the Mycoplasma pneumoniaeinfection may be one of the risk factors of the bronchial asthma.