鲍氏不动杆菌耐药与抗菌药物使用强度的相关性分析

Correlation between antimicrobial resistance of Acinetobacter baumannii and DDDs

目的评价抗菌药物的使用与抗菌药物对医院感染鲍氏不动杆菌耐药性之间的关系,以期为临床合理使用抗菌药物提供依据。方法监测2006年1月1日-2010年12月31日阿米卡星等每年的抗菌强度和主要抗菌药物对鲍氏不动杆菌的耐药率。结果在同期相关分析中,亚胺培南/西司他丁、氨曲南、氨苄西林/舒巴坦的抗菌药物使用强度与鲍氏不动杆菌耐药率的相关系数分别为0.9526、0.9565、0.9866,具有一般相关性(P<0.05),头孢哌酮/舒巴坦的抗菌药物使用强度与鲍氏不动杆菌耐药率的相关系数为0.9717,具有显著相关性(P<0.01)。结论合理使用抗菌药物以降低细菌耐药迫在眉睫,应根据半衰期及抗菌药物后效应制定出最佳给药方案,根据药敏试验结果合理选用抗菌药物。

OBJECTIVE To evaluate the correlation between antimicrobial resistance of hospital acquired Acinetobacter baumannii and DDDs so as to provide the basis for clinical rational use of antibacterial drugs.METHODS The DDDs of the antibiotics such as amikacin were monitored in each year from Jan 1st to Dec 31,st 2010,and the drug resistance rates of the A.baumannii to the main antibiotics were observed.RESULTS The contemporaneous correlation analysis showed that the correlation coefficients between the DDDs of such antibiotics as imipenem/ cilastatin,aztreonam,ampicillin/sulbactam and the drug resistance rate of A.baumannii were 0.9526,0.9565and 0.9866,respectively,indicating the general relativity（P〈0.05）.The correlation coefficient between the DDDs of cefoperazone/sulbactam and the drug resistance rate of A.baumannii was 0.9717,showing the significant relativity（P〈0.01）.CONCLUSIONIt is urgent to reasonably use antibiotics so as to reduce the bacterial resistance,and it is necessary to develop the best drug administration program based on the half-life and post antibiotic effect and to reasonably use antibiotics on the basis of the result of drug susceptibility testing.