雷贝拉唑服药频次对缓解反流性食管炎症状的比较研究

Comparative study of rabeprazole medication frequency in relieving symptoms of reflux esophagitis

目的比较雷贝拉唑两种服药频次对缓解反流性食管炎症状的影响,进一步探讨反流性食管炎的治疗方案。方法 241例胃镜确诊的反流性食管炎患者,随机分为2组,甲组给予雷贝拉唑10 mg每日2次服药,乙组给予雷贝拉唑20 mg每日1次服药。4周后比较各组患者烧心及反流症状的缓解情况。结果甲组121例患者全部有烧心症状,82例有反流症状;乙组120例患者全部有烧心症状,84例有反流症状。治疗后甲组97例患者烧心症状缓解(缓解率80.2%);乙组79例患者烧心症状缓解(缓解率65.8%),2组比较差异有统计学意义(χ2=6.283,P<0.05)。甲组70例反流症状缓解(缓解率85.4%);乙组67例反流症状缓解(缓解率79.8%),2组比较差异无统计学意义(χ2=0.904,P>0.05)。结论雷贝拉唑10 mg每日2次服药,对烧心症状的缓解优于雷贝拉唑20 mg每日1次服药;2种服药频次对反流症状的疗效无明显差别。

Objective By comparing two medication frequency of rabeprazole in relieving symptoms of reflux esophagitis, to further explore the treatment options for reflux esophagitis. Methods All 241 reflux esophagitis patients diagnosed with endoscopy were randomly di- vided into two groups. Group A was treated with rabeprazole 10mg twice daily for medication, and Group B was given rabeprazole 20 mg once daily for medication. Four weeks after the treatment, the relief of heartburn and reflux symptoms in reflux esophagitis patients was compared. Results In group A, all 121 patients showed heartburn symptom and 82 patients had reflux symptom. As in group B, all 120 patients showed heartburn symptom and 84 patients had reflux symptom. After 4 weeks＂ treatment, 97 patients in group A with heartburn symptom relieved （ef- fective rate was 80.2%）. In group B, 79 patients with heartburn symptom relieved （effective rate was 65.8%）, and significant difference was seen in two groups （X2=6.283, P 〈0.05 ）. Meanwhile, in Group A, 70 patients with reflux symptom relieved （effective rate 85.4%） As in group B, 67 patients with reflux symptoms relieved （efficiency of 79.8% ）, and there was no statistical difference in two groups （X2=0.904, P 〉0.05 ）. Conclusion Rabeprazole 10mg twice daily is more effective than rabeprazole 20 mg once daily in relieving heartburn symptoms. No signifi- cant difference can be seen in relieving reflux symptoms between the two groups.