持续不卧床腹膜透析患者亚临床甲状腺功能减退与左心室收缩功能关系的研究

Association between subclinical hypothyroidism and left ventricle systolic function in patients with continuous ambulatory peritoneal dialysis

目的对持续不卧床腹膜透析(CAPD)患者中亚临床甲状腺功能减退(SCH)和左心室收缩功能之间的关系进行研究。方法采用横断面研究连续选取透龄超过3个月的CAPD患者51例,收集其人口学指标、临床及实验室数据。对SCH和左心室收缩功能之间的关系进行Logistic回归分析。结果 51例CAPD患者中,并发SCH者14例(27.45%)。经Logistic回归分析,校正年龄、合并糖尿病者、血清清蛋白和CRP后,发现亚临床甲减(β=-0.361,P=0.008)和CRP升高(β=0.378,P=0.011)均是CAPD患者左心室收缩功能下降的独立危险因素。结论在CAPD患者中,SCH和左心室收缩功能下降存在独立相关性。

Objective To study the association between subclinical hypothyroidism（SCH） and left ventricle systolic function in patients with continuous ambulatory peritoneal dialysis （CAPD）. Methods All 51 CAPD patients were enrolled in this cross-sectional study. The ba- sic demographic characteristics, clinical and laboratory data of the patients were collected. Multivariable logistic regression method was used to evaluate the association between SCH and the left ventricle systolic function. Results Among 51 CAPD patients, 14 cases（27,45%） were with SCH. After adjusting for age, combined with diabetes mellitus, serum albumin and CRP,SCH and increased CRP was independent risk factor with decresed LVEF （β=- 0.361 ,P =0.008 andβ= 0.378, P =0.011 ）. Conclusion The study suggests that subclinical hypothyroidism is com- mon and might be independent correlate with LVEF.