骨髓涂片与骨髓活检诊断骨髓增生异常综合征22例结果分析

Analysis of bone marrow smear and bone marrow biopsy in diagnosis of myelodysplastic syndrome in 22 cases

目的探讨在骨髓增生异常综合征(MDS)诊断中,骨髓涂片和骨髓活检的异同性。方法对22例MDS患者同步做骨髓涂片和骨髓活检切片,观察骨髓涂片和切片的形态学特征,并对其进行比较分析。结果活检切片对骨髓增生程度的判断明显优于涂片;涂片对红系病态造血的观察优于活检,而活检对原始细胞数量、网状纤维增生、粒系、巨核系病态造血观察优于涂片。结论骨髓涂片与骨髓活检在MDS的诊断、分型中各有优点,结合应用可提高MDS诊断的准确性。

Objective To explore the similarities and differences of bone marrow smear and bone marrow biopsy in the diagnosis of myelodysplastic syndrome（MDS）. Methods Bone marrow smear and bone marrow biopsy slice in 22 patients were simultaneously conducted .The morphological characteristics of bone marrow biopsy and bone marrow smear had been compared. Results The decision to the degree of bone marrow hyperplasia in bone marrow biopsy slice was prior to that in smear. The bone marrow smear slice was better in erythrocyte series than that in biopsy, but was worse in the primitive cells, hyperplasy of reticular fiber, dyshematopoiesis in the granulocyte series and megakary- ocytic series. Conclusion Bone marrow smear and biopsy slice have their own advantages in the diagnosis and classification of MDS. Com- bined detection can improve the accuracy in the MDS diagnosis.