抗抑郁剂对额叶脑梗死患者运动性失语的影响

The effects of antidepressant on Broca's aphasia in patients with frontal cerebral infarction

目的:观察急性额叶脑梗死致运动性失语患者使用抗抑郁剂(舍曲林片)治疗后对失语的改善程度的变化,为舍曲林治疗额叶脑梗死后运动性失语提供临床依据。方法:选择急性额叶脑梗死患者60例,随机分为对照组30例和治疗组30例,对照组采用常规治疗,治疗组除常规治疗外,加用舍曲林50 mg,睡前1次。两组疗程均3周。两组患者分别于治疗前和治疗后3周分别对患者进行疗效评价。结果:两组在治疗3周后运动性失语均有改善,治疗组改善程度明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论:舍曲林片治疗急性额叶脑梗死患者运动性失语有明显的疗效,有利于运动性失语的恢复。

Objective To observe the improvement of broca＇s aphasia in acute frontal lobe infarction patients after antidepressant（sertraline tablets） therapy.Methods A total of 60 patients with acute frontal lobe infarction were randomly assigned to receive either conventional treatment or sertraline tablets（50 nag） once before sleep based on conventional treatment.Therapeutic evaluation were obtained from both groups before and 3 months after the treatment.Results After a 3-week thrapy improvement was observed in both groups.The effect of sertraline tablets group differed significantly compared with control group（P 〈 0.05）.Conclusion Treatment of Broca＇s aphasia in acute frontal lobe infarction patients with sertraline tablets leads to better curative effect and recovery.