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低剂量电离辐射诱导的兴奋性效应-肿瘤免疫治疗的新希望 被引量：5

Low dose radiation-induced hormesis is a new promising strategy to improve therapeutic effect of immunotherapy
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摘要 低剂量电离辐射（LDR）诱导的兴奋性效应（hormesis）能增强受照机体的固有免疫和适应性免疫反应。以树突状细胞（DC）为基础的肿瘤免疫治疗开始于20世纪60年代，实验证实免疫治疗能在某种程度上提升抗肿瘤免疫应答和抑制肿瘤生长和转移。通过总结分析近几年的文献报道，可了解兴奋性效应增强免疫治疗临床效果的可能性。 Low dose radiation （LDR）-induced hormesis could largely strengthen innate immune re- sponse and adaptive immune response~ Dendritic cells（DC）-based immunotherapy begun in the 1960＇ s, Cur- rently, abundant related literatures have been proved that immunotherapy could enhance antitumor immune re- sponse and inhibit tumor growth, metastasis to some extent~ This review summarized recent reports and out- looked the possibility that whether hormesis could enhance the clinical effects of immunotherapy
作者 刘兵 信瑞 国维纳 王红勇
机构地区 吉林大学公共卫生学院放射医学卫生部重点实验室 吉林大学第二医院放射线科 放疗科 吉林大学护理学院
出处 《国际免疫学杂志》 CAS 2013年第4期271-275,共5页 International Journal of Immunology
关键词 低剂量电离辐射 兴奋性效应 树突状细胞 肿瘤免疫治疗 Low dose radiation Hormesis Dendritic cells Immunotherapy
分类号 R730.51 [医药卫生—肿瘤]
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共引文献15

同被引文献77

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引证文献5

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国际免疫学杂志
2013年 第4期

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