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新型共刺激分子B7-H6的研究进展 被引量：2

The last advance of the study on the new co-inhibitory molecule B7-H6
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摘要 B7-H6是近年来发现的共刺激分子B7家族新成员，主要表达于肿瘤组织，B7-H6是B7家族第一个特异表达在肿瘤组织中的成员，能够促进NK细胞的活化，负向调节肿瘤逃逸和固有免疫。目前对于B7-H6与其配体NKp30的相互作用的确切机制尚未完全明确，故对近年来关于B7-H6的分子结构、表达与分布情况，配体分子NKp30与肿瘤的关系研究很有意义。 B7-H6 is a new member of immunologlobulin family which has been found recently. B7-H6 expression was detected with a relative abundance in tumor cells of distinct origin, but not in normal tissues. BT-H6 is the first instance of a tumor-specific B7 family member that can directly trigger NK cell activation, this down-regulation is a mechanism whereby a tumor would escape innate immunity. The ligand of B7-H6, as well as the mechanism of the B7-H6 signal pathway, has not been clear yet. Therefore, the lastest finding of structure, the ligand NKp30 and the role of BT-H6/NKp30 in the process of tumor were described in this re-
作者 韩艳玲 吕雪莹
机构地区 哈尔滨医科大学免疫学教研室
出处 《国际免疫学杂志》 CAS 2013年第4期287-289,共3页 International Journal of Immunology
关键词 B7-H6 NKp30 肿瘤 B7-H6 NKp30 Tumor
分类号 R392 [医药卫生—免疫学]
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参考文献16

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同被引文献49

  • 1Pende D,Parolini S,Pessino A,et al. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells [ J ]. J Exp Med,1999,190(10) : 1505-1516.
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  • 3Herrmann J, Berberich H, Hartmann J, et al. Homo-oligomerization of the activating natural killer ceil receptor NKp30 ectodomain in- creases its binding affinity for cellular ligands [ J ]. J Biol Chem, 2014,289(2) : 765-777.
  • 4Brandt CS, Baratin M, Yi EC, et al. The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans[J]. J Exp Med,2009,206(7) : 1495-1503.
  • 5Delahaye NF, Rusakiewicz S, Martins I, et al. Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromaltumors[J]. Nat Meal,2011,17(6) : 700-707.
  • 6Pogge von Strandmann E, Simhadri VR, yon Tresekow B, et al. Hu- man leukocyte antigen-B-associated transcript 3 is released from tumor ceils and engages the NKp30 receptor on natural killer cells [J]. Immunity,2007,27(6) : 965-974.
  • 7Fiegler N, Textor S, Arnold A, et al. Downregulation of the activa- ting NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK ceils [ J ] . Blood,2013,122 ( 5 ) : 684-693.
  • 8Muller T, Schlahsa L, Zhang HJ, et al. Allogeneic and xenogeneie anti-tumor effeet of callithrix jaechus natural killer ceils is depend- ent on NKp30 and BT-H6 interaction [ J ]. J Biol Regul Homeost A- gents,2014,28(2) : 183-193.
  • 9Kellner C, Maurer T, Hallack D, et al. Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell eytotoxieity [ J ]. J Immunol, 2012,189 ( 10 ) : 5037-5046.
  • 10Sehlecker E, Fiegler N, Arnold A, et al. Metalloprotease-mediated tumor cell shedding of BT-H6 ,the ligand of the natural killer cell- activating receptor NKp30 [ J ]. Cancer Res, 2014, 74 ( 13 ) : 3429 -3440.

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国际免疫学杂志
2013年 第4期

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