摘要
目的探讨空腹血糖受损人群腰围变化与新发糖尿病发病风险之间的关系。方法采用前瞻性队列研究法,以参加2006-2007、2010-2011年开滦集团健康体检的在职及离退休职工为研究对象,以符合人选标准的12657名职工作为观察队列,依据基线腰围四分位水平将观察对象分为4组,比较4组间糖尿病的发病率。用多因素logistic回归分析腰围与糖尿病发病风险的关系。结果在12657名的糖尿病前期空腹血糖受损人群观察队列中,男性为10697名,女性为1960名,年龄为(49.9±11.3)岁。至2010-2011年度健康体检时,调查对象糖尿病的年发病率为4.27%(1884/12657),男性人群年发病率为4.25%(1581/10697),女性为4.44%(303/1960),差异有统计学意义(P〈0.05)。随着腰围的增加,糖尿病的发病率逐渐升高,第一分位组、第二分位组、第三分位组、第四分位组的糖尿病的年发病率分别为2.19%(235/3083)、3.07%(333/3114)、4.47%(473/3037)、7.08%(843/3423);按性别分层后,男性4组糖尿病的年发病率分别为2.34%(213/2626)、3.06%(282/2645)、4.37%(393/2582)、7.00%(693/2844),女性4组的年发病率分别为1.38%(22/457)、3.12%(51/469)、5.05%(80/455)、7.45%(150/579)。相同腰围分组间女性糖尿病年发病率均高于男性,差异均有统计学意义(P〈0.05)。影响糖尿病的多因素logistic回归分析显示,校正年龄、性别等因素后,与第一分位组比较,第二、三、四分位组均增加糖尿病的发病风险[OR(95%CI)值分别为1.38(1.13-1.68)、1.79(1.47-2.09)和3.10(2.57-3.75)]。结论随着腰围的增加,糖尿病前期空腹血糖受损人群糖尿病发病风险增加。
Objective To explore the impact of the waist circumference change on new onset diabetes(NOD) in the impaired fasting glucose(IFG) population. Methods A total of 12 657 subjects who took part in the health examination from 2006 to 2007 and from 2010 to 2011 from the employees of Kailuan Group and met the inclusion criteria were selected as the observation cohort. Of the 12 657 subjects, 10 697 were male, 1960 were female, with age of (49.9 + 11.3) years old. According to the baseline waist circumference (WC) measurements and its quartile in the health examinations during 2006 to 2007, the observation population was divided into four groups (first, second, third and the fourth quartile groups). Multiple logistic regression analysis was used to test the relation between the increasing of WC and NOD. Results The incidences in the IFG population of NOD were 4. 27% ( 1884/12 657) in the total population ;4. 25% ( 1581/10 697 ) in male and 4.44% ( 303/1960 ) in females, respectively ( P 〈 0. 05 ). Along with increasing WC in the 4 quartile groups,the incidences of NOD was progressively increased,which were 2. 19% (235/3083), 3.07 % (333/3114) ,4. 47 % (473/3037) and 7.08% (843/3423), respectively; 2. 34% (213/2626) , 3.06% (282/2645) ,4. 37% (393/2582) , 7.00% (693/2844) in males and 1.38%
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2013年第7期622-626,共5页
Chinese Journal of Preventive Medicine
关键词
腰围
糖尿病前期
糖尿病
空腹血糖受损
Waist circumference
Prediabetic state
Diabetes mellitus
Impaired fasting glucose