期刊文献+

微波促进下2-取代苯并噁唑类化合物合成研究 被引量:3

Microwave Irradiation Promoted Synthesis of 2-Substituted Benzoxazoles
下载PDF
导出
摘要 研究了离子液体介质中、微波辐射促进下邻氨基苯酚与醛的缩合反应,并利用该反应合成了一系列2-取代苯并噁唑.与文献方法相比,所报道的新方法具有反应速度快、收率高以及对环境友好等诸多优势,从而为2-取代苯并噁唑类化合物的合成提供了一条新途径. A clean and efficient synthesis of 2-substituted benzoxazoles through tandem reactions of 2-aminophenols and aldehydes mediated with under MWI has been developed.Compared with literature methods toward 2-substituted benzoxazoles,the synthetic strategy presented in the paper has such advantages as enhanced reaction rate,high yield and environmental benigncy.
出处 《河南师范大学学报(自然科学版)》 CAS 北大核心 2013年第3期88-91,共4页 Journal of Henan Normal University(Natural Science Edition)
基金 国家大学生创新性实验计划项目
关键词 2-取代苯并噁唑 离子液体 微波 2-Substituted benzoxazoles ionic liquid microwave irradiation
  • 相关文献

参考文献8

  • 1Kckee M L, Kerwin S M, Synthesis. metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole an- alogs of UK-1 [J]. Bioorg Med Chem,2008,16(4) :1775 1783.
  • 2Ertan T, Yildiz I, Tekiner-Gulbas B, et al. Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial a- gents [J]. Eur J Med Chem,2009,44(2) :501-510.
  • 3Alper-Hayta S, Arisoy M, Temiz-Arpaei O, et al. Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitut- edphenyl/benzyl) 5- (2-benzofuryl) carboxamido benzoxazoles[J]. Eur J Med Chem, 2008,43 ( 11 ) : 2568-2578.
  • 4Huang J, Chan J, Chen Y, et al. A highly efficient palladium/copper cocatalytic system for direct arylation of heteroarenes: an unex- pected effect of Cu(Xantphos) I[J]. J Am Chem Soc, 2010,132 ( 11 : 3674-3675.
  • 5Bose D S, Idrees, M. Dess-Martin periodinane mediated intramolecular cyclization of phenolic azomethines: a solution phase strategy to- ward benzoxazoles and benzo thiazoles[J]. Synthesis,2010(3) :398-402.
  • 6Guru M M, Ali A, Punniyamurthy T. Copper-mediated synthesis of substituted 2-aryl benzimidazoles and 2-arylbenzoxazoles via C-H functionalization/C-N/C-O bond formation[J]. J Org Chem,2011,76(13) 5295 5308.
  • 7Ranke J, Stolter S, Str6mann R. Design of sustainable chemical products, the example of ionic liquids[J]. Chem Rev,2007,107(6): 2183-2206.
  • 8Dallinger D, Kappe C O. Microwave-assisted synthesis in water as solvent[J]. Chem Rev,2007,107(6) :2563-2591.

同被引文献9

引证文献3

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部