肾衰宁胶囊联合血液透析治疗慢性肾衰竭的疗效观察

The clinical effects of shenshuaining capsule combined with hemodialysis treatment in of chronic renal failure

目的:研究肾衰宁胶囊联合血液透析治疗慢性肾衰竭的临床疗效,指导临床合理用药。方法:将56例患者随机分为两组,治疗组患者和对照组患者均进行血液透析治疗,治疗组在血液透析的基础上加服肾衰宁胶囊4粒/次,tid。3个月后观察患者的临床症状以及血肌酐、血尿素氮、肌酐清除率以及血红蛋白浓度等相应的生化指标进行疗效判定。结果:治疗组和对照组患者在治疗前一般资料相比无显著性差别,两组患者具有可比性。2组患者治疗后相比于治疗前,血肌酐和血尿素氮均具有明显的降低,肌酐清除率和血红蛋白浓度均有明显的上升(P<0.05)。治疗后治疗组的血肌酐和血尿素氮比对照组低,肌酐清除率和血红蛋白浓度比对照组高,差异也具有统计学意义(P<0.05)。治疗组的总有效率也明显优于对照组,差异具有统计学意义(P<0.05)。结论:肾衰宁胶囊联合血液透析治疗慢性肾衰竭的临床疗效优于单纯的血液透析治疗,肾衰宁胶囊应作为临床血液透析治疗慢性肾衰竭的常用辅助药物。

OBJECTIVE To investigate the clinical effects of shengshuaining capsule combined with hemodialysis treatment in chronic renal failure,and provide some knowledge for the rational use of drugs.METHODS 56 cases of chronic renal failure patients were divided into two groups.Both groups were treated with hemosialysis.And the treatment group was added with four shenshuaining capsules each time,three times a day.The clinical symptoms,serum creatinine,blood urea nitrogen,creatinine clearance rate and hemoglobin were investigated after three months.RESULTS There was no significant difference between treatment group and control group in clinical symptoms before treatment,and the two groups were comparable.The serum creatinine and blood urea nitrogen of both groups were significantly decreased after treatment.The creatinine clearance rate and hemoglobin of both groups were significant increased after treatment.And the serum creatinine,blood urea nitrogen of treatment group was lower than that of control group.The creatinine clearance rate and hemoglobin of treatment group was higher than that of control group.The total efficiecy of treatment group was higher than that of control group.And all the differences were significant.CONCLUSION Shenshuaining capsule combined with hemodislysis was better than hemodislysis alone in treatment of chronic renal failure;Shenshuaining capsule could be used as an auxiliary drug and combined with hemodialysis in treatment of chronic renal failure.