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丁酸盐的生物学功能和机制及其在动物生产中的应用 被引量：16

Biological Functions and Mechanism of Butyrate and Its Application in Animal Production
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摘要 本文综述了丁酸盐在维持动物肠道健康、免疫调节、神经保护、基因表达调控等方面的作用及其相关机制,并且简要介绍了其在动物生产中的应用,旨在为今后的生产实践提供参考。 This paper reviewed functions and mechanism of action of butyrate in intestinal health maintenance, immunomodulation, neuroprotection, and regulation of gene expression, and briefly introduced its application in animal production to provide references.
作者 刘锐钢 肖英平 陈安国
机构地区 浙江大学动物科学学院
出处 《动物营养学报》 CAS CSCD 北大核心 2013年第6期1180-1188,共9页 CHINESE JOURNAL OF ANIMAL NUTRITION
基金 浙江省地方企业委托项目(H20080692)
关键词 丁酸盐 生物学功能 作用机制 动物生产 butyrate function mechanism animal production
分类号 S816.7 [农业科学—饲料科学]
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参考文献62

  • 1LEONEL A J, ALVEREZ-LEITE J I. Butyrate:impli- cations for intestinal function [ J ]. Current Opinion in Clinical Nutrition and Metabolic Care, 2012,15 ( 5 ) : 474 - 479.
  • 2CANANI R B, COSTANZO M D,LEONE L. The ep- igenetic effects of butyrate :potential therapeutic impli- cations for clinical practice [ J ] . Clinical Epigenetics, 2012,4(1) :4.
  • 3MACFARLANE G T, MACFARLANE S. Fermenta- tion in the human large intestine : its physiologic conse- quences and the potential contribution of prebiotics [ J ]. Journal of Clinical Gastroenterology, 2011,45 : S120 - S127.
  • 4GONCALVES P, ARAUJO J R, MARTEL F. Charac- terization of butyrate uptake by nontransformed intesti- nal epithelial cell lines [ J ]. Journal of Membrane Biol- ogy ,2011,240( 1 ) :35 -46.
  • 5BAI Z G, ZHANG Z T, YE Y J, et al. Sodium buty- rate induces differentiation of gastric cancer cells to in- testinal cells via the PTEN/phosphoinositide 3-kinase pathway [ J ]. Cell Biology International, 2010, 34 (12) :1141 -1145.
  • 6HUDCOVIC T, KOLINSKA J, KLEPETAR J, et al. Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-alpha and interleu- kin-18 in BALB/c and severe combined immunodefi- ciency mice [ J ]. Clinical and Experimental Immunolo- gy ,2012,167 ( 2 ) :356 - 365.
  • 7HATAYAMA H, WASHITA J, KUWAJIMA, et al. The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T [ J ]. Biochemical and Biophysical Research Communications ,2007,356(3 ) :599 -603.
  • 8PENG L Y, LI Z R, GREEN R S, et al. Butyrate en- hances the intestinal barrier by facilitating tight junc- tion assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers [ J ]. The Journal of Nutrition, 2009,139 ( 9 ) : 1619 - 1625.
  • 9Roberto Berni Canani,Margherita Di Costanzo,Ludovica Leone,Monica Pedata,Rosaria Meli,Antonio Calignano.Potential beneficial effects of butyrate in intestinal and extraintestinal diseases[J].World Journal of Gastroenterology,2011,17(12):1519-1528. 被引量：52
  • 10STEINMANN J, HALLDORSSON S, AGERBERTHB, et al. Phenylbutyrate induces antimicrobial peptide expression [ J ]. Antimicrobial Agents and Chemothera- py ,2009,53 ( 12 ) :5127 - 5133.

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动物营养学报
2013年 第6期

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