七花牌七灵宝软胶囊缓解体力疲劳功能评价

Evaluation of relieving physical fatigue function of Qilingbao Soft Capsule with Qihua Brand

目的对以三七提取物、黄芪提取物、灵芝提取物等为原辅料制成的保健食品七花牌七灵宝软胶囊,依据《保健食品检验与评价技术规范》(2003年版)进行缓解体力疲劳功能研究。方法根据人口服推荐用量,设样品低、中、高剂量组分别为200、400、800mg/kg(分别相当于人体推荐用量的5、10、20倍),同时设一个阴性对照组,每组10只动物。分别ig给予10、20、40mg/mL的七灵宝软胶囊溶液,给药体积为20mL/kg,对照组给予等体积的玉米胚芽油,每天1次,连续30d。结果该样品对小鼠的体质量增长无影响;具有延长小鼠的负重游泳时间的作用;能减少或抑制疲劳小鼠血清尿素氮的产生;具有促进小鼠的肝糖原储备的作用;能减少小鼠运动后的血乳酸曲线下面积。结论七花牌七灵宝软胶囊具有缓解小鼠体力疲劳的作用。

Objective To evaluate the relieving physical fatigue function of health food Qilingbao Soft Capsule （QSC） with Qihua Barnd which was made from the extracts of Notoginseng Radix, Astragali Radix, Ganoderma Lucidum seu Japonicum, and so on, according to ＂Health food Inspection and Evaluation Technical Specifications＂ （2003）. Methods According to the recommended oral dosage, the mice were divided into control, low-, mid-, and high-dose （200, 400, 800 mg/kg, equivalent to 5, 10 and 20 times of recommended dosage for human body） groups, 10 mice in each group. The mice in treatment groups were administered with QSC （10, 20, and 40 mg/mL, with the volume of administration 20 mL/kg） while the mice in the control group were given equal volume of corn oil, once daily for continuous 30 d. Results The samples had no effect on the increase of body weight in mice, had the function of prolonging the weight-bearing swimming time in mice, could reduce or inhibit the generation of serum urea in mice with fatigue, had the effect of promoting the liver glycogen reserves of mice, and decreased the area under blood lactate curve of mouse postexercise. Conclusion The QSC has the function of relieving the physical fatigue in mice