摘要
目的考察玻璃瓶、聚氯乙烯软袋(PVC)、聚丙烯可立袋(PP)、非聚氯乙烯复合膜软袋(NPVC)4种包装材料在葡萄糖和氯化钠两种溶媒大输液中对丹参酮ⅡA磺酸钠注射液的吸附情况。方法将丹参酮ⅡA磺酸钠注射液分别配制于4种材质的0.9%氯化钠注射液及5%葡萄糖注射液中,于0、0.25、0.5、1、2、4、6h取样,用紫外可见分光光度法测定丹参酮ⅡA磺酸钠的吸光度值,考察其量的变化。结果 6h内丹参酮ⅡA磺酸钠在4种材质两种输液中量的变化低于±4%,组间比较差异无显著性(P>0.05)。结论丹参酮ⅡA磺酸钠注射液在4种不同材质的输液中稳定性良好。
Objective To investigate the absorptivities of Sulfotanshinone Sodium Injection (SSI) in glass bottles, polyvinylidene chlorid (PVC) plastic infusion bags, polypropylene plastic (PP) infusion bottles and non-polyvinylidene chlorid (NPVC) infusion bags respectively for 6 h. Methods The drugs were separately added to different infusion sets. The samples of drug solutions were collected after 0, 0.25, 0.5, 1, 2, 4, and 6 h and analyzed by UV methods. Results The changes of the sulfotanshinone sodium contents in each compatible solution within 6 h were less than 4% (P 0.05). Conclusion SSI has the good stability in the infusion sets made of four different meterials.
出处
《药物评价研究》
CAS
2013年第3期196-198,共3页
Drug Evaluation Research
基金
深圳市科技计划项目(200903048)