严重体表烧伤合并吸入性损伤病人血栓素和前列环素的变化

Changes of Thromboxane and Prostacyclin in Severe Body Surface Burn Patients Complicated with Inhalation Injury

烧伤病人41例,分为吸入性损伤和无吸入性损伤两组。结果显示,吸入性损伤组血浆和肺组织TXB_2和TXB_2/6-酮-PGF_1α比值均明显增高,循环血小板微聚物比率明显降低,全血粘度升高。病理见肺组织充血、水肿、出血和血栓形成。TXB_2和TXB_2/6-酮-PGF_1α比值的动态变化与吸入性损伤病人呼吸衰竭的临床进程基本一致。这提示TXA_2/PGI_2比值失衡是导致体表烧伤合并吸入性损伤肺水肿和呼吸衰竭的机理之一。

Forty-one burn patients were divided into inhalation injury and non-inhalation injury groups.It was found that in the inhalation injury group,TXB2 level and TXB2/G-keto-PGF1α ratio in plasma and lung tissue were significantly elevated,circulatory platelet aggregate ratio markedly decreased,and blood viscosity greatly increased.Histopathologically,congestion,edema,hemorrhage and thrombosis were seen in lung tissue.The changes of TXB2 level and TXB2/6-keto-PGF1αratio were parallel to the clinical course of the development of respiratory failure in the patients with body surface burns complicated with inhalation injury.It is believed that the imbalance of TXA2/PGI2 is one of the factors of respiratory failure in severe body surface burns complicated with inhalation injury.