树突状细胞在诱导免疫耐受中作用机制的研究进展

Research Progress on Effects and Mechanisms of Dendritic Cells in the Induction of Immune Tolerance

树突状细胞在抗原识别、递呈、诱导T细胞增殖和抗原特异性免疫反应中起中枢作用。近年来研究发现该细胞还可诱导机体的免疫耐受,这一作用是目前免疫耐受技术研究的热点。作者从中枢免疫耐受和外周免疫耐受2个角度阐述了树突状细胞在免疫耐受中的研究现状,并从调节性T细胞、表面抑制分子、成熟状态、微环境、细胞内信号传导5个方面对树突状细胞诱导免疫耐受的机制作了归纳总结。通过这一综述,以期为树突状细胞免疫耐受的研究提供相关资料。

The dendritic cells played a central role in antigen recognition,offer,induced proliferation of T cells and antigen- specific immune response. In recent years, it was found that the cells could also induce immune tolerance and this role was a hotspot in immune tolerance research. This article elaborated the research satus from two aspects, the central and peripheral tolerance. The mechanisms were summarized from five aspects,the regulatory T cells, the surface of the inhibitory molecule, mature state, the microenvironment and intracellular signal transduction. The overview would provide relevant informations for the research of the dendritic cell tolerance.