摘要
树突状细胞在抗原识别、递呈、诱导T细胞增殖和抗原特异性免疫反应中起中枢作用。近年来研究发现该细胞还可诱导机体的免疫耐受,这一作用是目前免疫耐受技术研究的热点。作者从中枢免疫耐受和外周免疫耐受2个角度阐述了树突状细胞在免疫耐受中的研究现状,并从调节性T细胞、表面抑制分子、成熟状态、微环境、细胞内信号传导5个方面对树突状细胞诱导免疫耐受的机制作了归纳总结。通过这一综述,以期为树突状细胞免疫耐受的研究提供相关资料。
The dendritic cells played a central role in antigen recognition,offer,induced proliferation of T cells and antigen- specific immune response. In recent years, it was found that the cells could also induce immune tolerance and this role was a hotspot in immune tolerance research. This article elaborated the research satus from two aspects, the central and peripheral tolerance. The mechanisms were summarized from five aspects,the regulatory T cells, the surface of the inhibitory molecule, mature state, the microenvironment and intracellular signal transduction. The overview would provide relevant informations for the research of the dendritic cell tolerance.
出处
《中国畜牧兽医》
CAS
北大核心
2013年第6期100-103,共4页
China Animal Husbandry & Veterinary Medicine
基金
山东省自然科学基金(ZR2011CL013)
国家自然科学基金(81202308)
关键词
树突状细胞
免疫耐受
作用机制
dendritic cell limmune tolerance~ mechanism of action