桑杏平喘颗粒的亚慢性毒性研究

Study on Subchronic Toxicity of Sangxing Pingchuan Granules

本试验旨在了解桑杏平喘颗粒的安全性,为临床用药提供数据支持。选用健康Wistar大白鼠80只,随机分成4组(1个对照组和3个试验组),每组20只,雌雄各半。对照组灌服生理盐水,试验组分别以桑杏平喘颗粒煎剂相当于30、15、3g/kg体重(按照原药材计)灌胃给药,连续给药30d,记录体重变化,在给药10、20、30d后采血,测定血常规指标,30d时取心脏、肝脏、脾脏、肺脏、肾脏称重并计算脏器系数,制作心脏、肝脏、脾脏、肺脏、肾脏组织切片,进行病理组织学检查。试验结果表明,桑杏平喘颗粒对动物机体影响较小,是一种适合临床应用的低毒、安全的中兽药制剂。

In order to kown the safety of sangxing pingchuan granules and provide data support for the clinical medication, 80 Wistar rats were randomly divided into four groups （one control group and three treatment groups）, and each group had 20 rats. The control group was taken normal saline by intragastric administration. The three treatment groups were grvaged with water solutions of sangxing pingchuan granules at doses of 30, 15, 3 g（crude drug） （kg ~ BW）, respectively. The drug was fed for 30 days continuously, and changes of body weight were recorded. The blood was collected every nine days for the analy- sis on some blood routine indices. The heart, liver, spleen, lung and kidney were taken and weighed to calculate organic inde- xes, then made intotissue sections for histopathological analysis. The results showed that sangxing pingchuan granules affected less on rats. So it was a low toxic and safe traditional Chinese medicine preparation which was suitable for clinical application.