丁苯酞联合烟酸占替诺治疗一氧化碳中毒迟发性脑病临床疗效观察

Study on effect of NBP combined with xantinol nicotinate in treating with DEACMP

目的:探讨丁苯酞联合烟酸占替诺治疗一氧化碳中毒迟发性脑病患者的临床疗效。方法:30例对照组患者应用高压氧及脑细胞活化剂等常规治疗,30例治疗组患者在常规治疗基础上再联合丁苯酞和烟酸占替诺治疗。于治疗前、发病1周、治疗1个月后分别进行日常生活能力评定(BI)、长谷川痴呆量表评定(HDS),比较2个量表值的变化;评价临床疗效:对比发病1周和2个疗程后头颅核磁变化。结果:入院时2组患者BI、HDS评分差异无显著性(P>0.05)。治疗1个月后,2组BI、HDS评分均有不同程的提高,治疗组评分提高更明显(P<0.05)。2组治疗1个月后,临床疗效,治疗组总有效率93.3%,对照组66.7%,治疗组疗效明显优于对照组(P<0.05)。头颅核磁对比显示治疗组疗效显著(P<0.05)。结论:丁苯酞联合烟酸占替诺治疗一氧化碳中毒迟发性脑病有良好疗效,应是临床不可忽视的治疗方案。

Objective：To explore effect of NBP combined with xantinol nicotinate in treating with DEACMP.Methods：Conventional therapy included high pressure oxygen and brain cell activator were used to 30 patients as the control group.NBP combined with xantinol nicotinate added to conventional therapy were used to 30 patients as the treatment group.BI and HDS were used to evaluate clinical effects for 3 times;prior treatment,after 1 week illness and after 1 month treatment.Head MRI was compared between 1 week illness and 2 course of treatment.Results：There wasnot significant difference in two groups by BI and HDS prior treatment（P0.05）.There was an increase in two groups by BI and HDS afterl month treatment,and those in the treatment group had improved further.After 1 month treatment, the total effective rate in the treatment group（93.3%） was higher than that in the control group（66.7%）（P0.05）.The effect in the treatment group was better than that in the control group by Head MRI（P0.05）.Conclusion：NBP combined with xantinol nicotinate had positive effects in treating with DEACMP.