舍曲林治疗老年抑郁症的研究

Effect of sertraline for senile depression

目的:探讨舍曲林治疗老年期抑郁症的效果。方法:60例符合诊断标准的老年期抑郁症患者随机分为舍曲林组和文拉法辛组,疗程8周。采用汉密尔顿抑郁量表(HAMA)评定疗效,(TESS)量表评定药物的安全性。结果:在第1周末研究组(舍曲林组)有效率为32.00%,对照组(文拉法辛组)有效率为12.00%。2组有效率有显著差异(x^2=3.65、P<0.05)。治疗8周末研究组总有效率91.35%,对照组总有效率85.32%,两组总有效率无显著差异(x^2=0.165、P>0.05),研究表明两者总体疗效相当。2组的TESS评分在治疗后1、2、4及8周末差异无统计学意义(P>0.05)。结论:舍曲林治疗老年期抑郁症起效快、安全性好,副作用少。

Objective：To explore the effect of sertraline in treatment of senile depression patients.Methods：60 patients who met the international classification of diseases -10（ICD - 10 ） diagnostic criteria for senile depression were recruited,they were randomly assigned to venlafaxine group and sertraline group for 8 weeks treatment.Hamilton depression rating scale（HAMA）,was used to evaluate the effect.Treatment emergent symptoms scale（TESS） was used to evaluate the safety.Results：After 1 week＇s treatment,the effective rate of the study group（sertraline group）was 32.00%,the control group（venlafaxine group）was 12.00%,the statistical difference was significant （x ~2=3.65、P0.05）.A fter 8 weeks＇ treatment,the total effective rate of the study group was 91.35%,the control group was 85. 32%.There were no significant difference（x^2 =0.165.,P0.05）.There were no significant differences between the two groups in the TESS score at the end of 1 week,2weeks,4weeks and 8weeks.Conclusion：Sertraline had the advantage of rapid onset,good safety and few side effects in the treatment of senile depression.