蜕膜组织中树突状细胞DEC-205及HLA-G的表达与子痫前期的关系研究

The relationship between the different expressions of dendritic cells in decidua basalis and preeclampsism

目的探讨蜕膜组织中抗原提呈细胞-树突状细胞(Dcs)的数量及对HLA-G的抗原提呈作用与子痫前期发病的关系。方法取36例子痫前期患者(试验组)及36例年龄配对的正常产妇的蜕膜组织(对照组),应用免疫组化法分别检测两组胎盘蜕膜组织树突状细胞中DEC-205+和HLA-G+的表达差异。结果与对照组相比,子痫前期患者胎盘蜕膜组织中DEC-205+树突状细胞明显增多,而蜕膜组织中HLA-G+树突状细胞明显减少,差异有显著性。结论子痫前期患者胎盘蜕膜组织中树突状细胞数量明显增多,而HLA-G表达明显下降,说明蜕膜组织中树突状细胞对HLA-G的抗原提呈作用降低与子痫前期的发病有一定关系。

[ Objective ] To research the relationship of the number of Dcs in decidua basalis,the different antigen presentations of HLA-G in decidua basalis and preeclampsism. [Methods] 36 decidual samples from severe preeclamptic pregnancies and 36 from gestational age-matched normal pregnancies were collected as study group and control group, respectively and the different expression of Dcs was investigated. [ Results ] Compared with their counterparts in the control group, the level of DEC-205＋ Des in the study group was significantly increased, and the level of HLA-G＋ Des in the study group was significantly decreased. [ Conclusion ] The level of subtype DEC-205＋ Dcs is high and the level of subtype HLA-G＋ Dcs in decidua basalis is low, which likely reflects a slow down in antigen presentation of HLA-G in Dcs in decidua basalis may be related to the etiology of preeclampsia.