摘要
家兔急性双光气中毒20min后(中毒浓度195～240ug/L),于1,6,12和24h进行骨脏组织学和超微结构观察.光镜下见肾小管上皮细胞普遍浊肿,少数细胞嗜酸性变.电镜下见肾小管上皮细胞、血管内皮细胞等有损伤性变化,表现为细胞水肿,线粒体肿胀,内质网扩张等.少数肾小管上皮细胞胞核固缩、碎裂,胞浆崩解或退变,甚至成为裸核及胞浆碎片,提示为一种细胞衰亡现象.作者讨论了病变的程度、性质及发生机理.
Histological and ultrastnictural changes of kidneys were studied in 8 rabbits following acute exposure to diphosgene at a concentration of 195-240 μg/L in 2 batches for 20 minutes. Prominent regressive changes were observed in vascular cndothclial cells and podocytes of the glomcruli, and the tubular epithelial cells, especially in the later. The injury of most cells was reversible, and only a few cells had apoplosis. The nature, significance and mechanism of these changes arc discussed in this paper.
出处
《第四军医大学学报》
1991年第1期18-20,共3页
Journal of the Fourth Military Medical University
关键词
双光气中毒
超微结构
肾
兔
kidney
ultrastructure
diphosgene
rabbit
apoptosis
