经皮给药系统研究进展

Advances in Transdermal Drug Delivery Systems

经皮给药系统把皮肤作为可行的给药路径,使药物经过皮肤进入体内起治疗作用,具有使用方便、降低个体给药差异、延长药物作用时间、降低给药次数、血药浓度稳定和降低药物毒副作用等优点。经皮给药可代替传统的口服给药和注射给药,具有广阔的发展空间。

Transdermal drug delivery systems, using skin as a viable route of administration, were designed to deliver a therapeutically effective amount of drug across a patient＇s skin for therapeutic purpose. They were characterized by easy using, reducing the differences in self - administration, extending the drug action time, reducing the frequency of admin- istration, stable plasma concentration and reducing the side effects of drugs, etc. The research status of the transdermal drug delivery system was reviewed. Transdermal drug delivery systems offered an attractive alternative to the conventional drug delivery methods of oral administration and injection, with a broad perspective.