芪参益气滴丸对慢性心力衰竭患者心功能及血浆超敏C反应蛋白和B型脑钠肽的影响

Effect of Qishen Yiqi Dripping Pills on Heart Function and High-sensitivity C-reactive Protein and B-type Brain Natriuretic Peptide Lvels in Patients with Chronic Heart Failure

目的:探讨芪参益气滴丸对慢性心力衰竭(CHF)患者心功能及血浆超敏C反应蛋(hs-CRP)和B型脑钠肽(BNP)的影响。方法:120例患者随机分为治疗组和对照组,均给予抗心力衰竭常规治疗,治疗组在常规治疗基础上加用芪参益气滴丸,疗程12周。治疗前后用彩色多普勒测定心功能指标左室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD);测定血浆hs-CRP和BNP水平。结果:两组患者治疗12周后临床疗效比较,差异有统计学意义(P<0.05);两组治疗后心功能指标LVEF,LVESD,LVEDD水平比较,差异均有统计学意义(P<0.01);两组治疗后hs-CRP,BNP水平比较,差异均有统计学意义(P<0.01)。结论:CHF患者在常规治疗基础上加用芪参益气滴丸治疗,可明显降低血浆hs-CRP及BNP水平,同时降低LVESVI,LVEDVI,增加LVEF,改善心功能。

Objective： To investigate the effect of Qishen Yiqi dripping pills on heart function and highsensitivity C-reactive protein（hs-CRP） and B-type brain natriuretic peptide（BNP） levels in the patients with chronic heart failure.Method： One hundred and twenty CHF patients were divided into routine therapy group and Qishen Yiqi dripping pills group.Left ventricular ejection fraction（LVEF）,left ventriculay end systolic diameter（LVESD） and left ventrieular end diastolic diameter（LVEDD） before and after treatment were detected.Serum hs-CRP and BNP were measured by rapid fluorescence immunoassay.Result： LVEDD and LVESD were shortened,LVEF was improved in Qishen Yiqi dripping pills group（P〈0.05）.Concentrations of serum hs-CRP and BNP levels were decreased in Qishen Yiqi dripping pills group after treatment（P〈0.01）.Conclusion： The heart function is further improved,concentrations of serum hs-CRP and BNP levels are further decreased by treated with Qisben Yiqi dripping pills in heart failure patients.