补肾方联合腧穴热敏灸治疗排卵障碍性不孕

Clinical Observation on Treatment of Sterility by Bushen Decoction with Moxibustion of Temperature Sensitive Acupoint

目的:探讨补肾方联合腧穴热敏灸治疗排卵障碍性不孕(肾阳虚型)的临床疗效及作用机制。方法:60例患者随机分为治疗组和对照组各30例,治疗组采用补肾方联合腧穴热敏灸,对照组单纯内服补肾方。均连续3个月。测定基础体温(BBT);经阴道B超监测主卵泡直径和子宫内膜厚度;检测血清中卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、泌乳素(PRL)和睾酮(T)水平。观察组1年内妊娠率。结果:治疗组总有效率(90.00%)优于对照组(60%)(P<0.05);治疗组中医证候总有效率(70.00%)优于对照组(43.33%)(P<0.01);治疗组妊娠率(63.33%)优于对照组(26.67%)(P<0.05);治疗组主卵泡直径和子宫内膜厚度增加优于对照组(P<0.01);治疗组BBT复常率(70.00%)优于对照组(33.33%)(P<0.01);治疗组FSH、LH和E2较对照组上升更明显(P<0.05)。结论:补肾方联合腧穴热敏灸能改善排卵障碍性不孕患者的激素水平,促使患者BBT恢复,改善临床症状,提高妊娠率。

Objective： To observe the treatment effects and safety of Bushen decoction with moxibustion of temperature sensitive acupoint on sterility due to anovulation,and to explore the mechanism of action of the treatment in curing sterility.Method： Sixty patients with sterility due to anovulation were randomly divided into two groups,the treatment group（30 cases） took the Bushen decoction with moxibustion of temperature sensitive acupoint,while the control group（30 cases） took Bushen decoction only.They were continuously treated for three months,and then tested basal body temperature（BBT）,and using trans-vaginal ultrasound to test the follicle diameter and thickness of uterine endometriums,and made detection of follicle stimulating hormone（FSH）,luteinizing hormone（LH）,estradiol2（E2）,prolactin（PRL）,testosterone（T） in serum.The pregnancy rate within 1 year was also investigated.Result： An efficiency of 90% in the treatment group was significantly better than 60% in the control group（P〈0.05）.The total efficiency of traditional Chinese medicine syndromes of the treatment group was 70% better than 43.33% of the control group（P〈0.01）.The pregnancy rate of the treatment group was 63.33% better than 26.67% of the control group（P〈0.05）.In treatment group the follicle diameter and endometrial thickness were increased and better than those of the control group（P〈0.01）.BBT recovery rate was 70% in treatment group better than 33.33% in control group（P〈0.01）.FSH,LH and E2 of the treatment group were significantly increased more than those in the control group（P〈0.05）.Conclusion： The therapy of Bushen decoction with moxibustion of temperature sensitive can improve anovulatory infertility with regulated hormone levels,prompting BBT recovery,improving clinical symptoms,and increasing pregnancy rate.