流行性出血热患者血浆中5-羟色胺的改变及其临床意义

Changes of plasma 5 - hydroxytryptamine in patients with epidemic hemorrhagic fever and its clinical significance

作者采用荧光分光光度法对76例流行性出血热(EHF)患者血浆5-羟色胺(5-HT)含量进行了研究.结果表明,EHF患者发热期、低血压期及少尿期5-HT含量(分别为143.52±27.79μg/L,130.42±22.65μg/L及144.08±27.67μg/L)均明显低于正常(161.45±31.30μg/L).多尿期开始回升,恢复期则达正常水平.5-HT的动态变化与血小板数量变化密切相关,提示5-TT主要来源于血小板,它们的减少主要是参与EHF出血的止血过程而被消耗.作者认为5-HT的测定可作为病情估价的辅助指标.

Rasma samples from 76 patients with epidemic hcmorrhagic fever (F.HF) were studied for 5- hydroxylryptamine ( 5 - HT ) content with fluorospectrophotometry . It was found that the content of 5 - HT was lower evidently in the febrile , hypotension and oliguric stages (143.52 ± 27.79 μg/L , 130.42 ± 2265 μg/L and 144.08 ±27.67 μg/L respectively )than in normal control (161.45 ± 31.30μg, L ), and picked up gradually in the diuretic stage (146.93 ± 24.47μg/L )and restored normal level in the convalescent stage (153.77 ± 2281 μg/L ). It was also found that the decrease and increase of peripheral platdct counts in various stages of F.HF wcrc closely associated with the kinetic changes of plasma 5 - HT content. It is suggested that plasma 5 - HT lake an effect on the hemoslatic process and play a part in the thrombosis . 5 - HT determination can be served as an accessory index of the state of the disease .