核分裂像计数判断乳腺癌腋下淋巴结转移

Counting mitotic figures to determine axillary lymph node metastasis in breast carcinoma

作者用计数核分裂像(MF)(个/mm^2)方法,研究乳腺浸润性导管癌36例的增生活性.结果表明,具有腋下淋巴结转移的原发瘤的MF(9.7±1.4)与无转移者(4.9±1.1)间存在显著差别(P<0.05).若按腋下淋肥结受累程度,淋巴结转移≤3个者为第1组,>3个者为第2组.则后者的MF(12.3±21)不仅与前者(5.8±0.4)而且与无转移组均有显著差别(P<0.05及P<0.02).但第1组与无转移组间却没有差别.这表明在低增生活性时,一个乳癌的增生活性并不必然反映其转移情况;而一旦达到相当水平时(12.3±21),不仅能反映乳癌的转移能力,而且还与转移程度有关.

Prolifcrative activity of 36 patients with breast carcinoma was studied by counting mitolic figures , which expressed as the number in mitolic figures per square millimeter . Our data revealed that primary tumour wilh axillary lymph node metastasis had a greater number of mitotic figures (9.7±1.4 ) than those without metastasis (4.9 ± 1.1, P<0.05 ). According to the axillary lymph nodes involved . the patients with metastasis were further divided into group 1 (fewer than or equal to three lymph nodes involved ). and group 2 (more than three ones involved ). Statistically , the latter had a great number in mitotic figures (12.3 _ 2.1 ) not only than the former (5.8 ± 0.4, P<0.05 ) but also than the group without metastasis (P<0.02 ). It suggests that low proliferation of a breast carcinoma may not be necessarily a determinant of its mclastauc capability , but once it is much higher (12.3 ± 2.1 ), it may reflect both mctastatic capability and extent of metastasis of breast carcinoma . Therefore , counting mitotic figures is a useful method for selecting the cases of breast carcinoma with high nsk .