透明质酸钠联合索利那新治疗女性间质性膀胱炎/膀胱疼痛综合征疗效观察(附20例报道)

Curative effect of sodium hyaluronate and solifenacin in female patients with IC/PBS

目的观察透明质酸钠联合索利那新治疗女性间质性膀胱炎/膀胱疼痛综合征(IC/PBS)的疗效。方法 20例女性IC/PBS患者分为A、B两组,每组10例,A组使用透明质酸钠膀胱灌注,每周1次,连续灌注12周,B组使用透明质酸钠膀胱灌注,每周1次,连续灌注12周,8周后同时口服索利那新,每天5 mg,连续4个月。评估患者治疗前、膀胱灌注第8周、第12周及治疗后6个月时的排尿次数、夜尿次数、最大排尿量和疼痛评分各项评价指标。结果两组患者治疗后各时间点的排尿次数、夜尿次数、最大排尿量和疼痛评分与治疗前相比较,均P<0.05。两组膀胱灌注12周及治疗后6个月时的各项评价指标与膀胱灌注8周相比较,均P<0.05。A组内膀胱灌注12周与治疗后6个月时各项评价指标相比较,均P<0.05,B组内膀胱灌注12周(口服索利那新4周)时的各项评价指标与治疗后6个月相比较,均P>0.05。A组膀胱灌注12周及治疗后6个月时各项评价指标与B组膀胱灌注12周(口服索利那新)及治疗后6个月相比较,除疼痛程度评分外,其余各项指标均P<0.05。结论膀胱灌注透明质酸钠能有效缓解女性IC/PBS临床症状,改善生活质量。膀胱灌注8周后联合使用索利那新比单独膀胱灌注能更好地缓解除膀胱区疼痛症状以外的临床症状。

【Objective】 To observe the efficacy of instillation of sodium hyaluronate therapy and peros solifenacin for the female patients with interstital cystitis/painful bladder syndrome（IC / PBS）.【Methods】 There were 20 IC / PBS patients in total.10 patients were given instillation of sodium hyaluronate therapy,once a week for 12 weeks（group A）.Other 10 patients received the same therapy and peros solifenacin at eighth week for four months（group B）.Micturition frequency,nocturia frequency,maximal micturition volume and odynuria degree score were assessed at baseline and then again after 8,12 weeks and 6 months.【Results】 Before therapy and after therapy,all the index of both groups patients had significant differences（P 0.05）.There were no significant differences in group A after 12 weeks and 6 months（P 0.05）.There were also no significant differences in group B after 12 weeks and 6 months（P 0.05）.After 12 weeks and 6 months,except for odynuria degree score,micturition frequency,nocturia frequency and maximal micturition volume had significant differences（P 0.05） between group A and group B.【Conclusion】 Instillation of sodium hyaluronate therapy can effectively relieve clinical symptom of IC / PBS and improve patients quality of life.It had a better effect with solifenacin after 8 weeks than sodium hyaluronate alone.